Virus DNA replication and the host DNA damage response

MD Weitzman, A Fradet-Turcotte - Annual review of virology, 2018 - annualreviews.org
Viral DNA genomes have limited coding capacity and therefore harness cellular factors to
facilitate replication of their genomes and generate progeny virions. Studies of viruses and …

DNA virus replication compartments

M Schmid, T Speiseder, T Dobner… - Journal of virology, 2014 - Am Soc Microbiol
Viruses employ a variety of strategies to usurp and control cellular activities through the
orchestrated recruitment of macromolecules to specific cytoplasmic or nuclear …

Role of the miR‐106b‐25 microRNA cluster in hepatocellular carcinoma

Y Li, W Tan, TWL Neo, MO Aung, S Wasser… - Cancer …, 2009 - Wiley Online Library
MicroRNAs are tiny RNA molecules which serve as important post‐transcriptional regulators
of gene expression. Dysregulated expression of microRNAs has been observed in human …

[PDF][PDF] An ATM/Chk2-mediated DNA damage-responsive signaling pathway suppresses Epstein-Barr virus transformation of primary human B cells

PA Nikitin, CM Yan, E Forte, A Bocedi, JP Tourigny… - Cell host & …, 2010 - cell.com
Summary Epstein-Barr virus (EBV), an oncogenic herpesvirus that causes human
malignancies, infects and immortalizes primary human B cells in vitro into indefinitely …

DNA damage signaling and p53-dependent senescence after prolonged β-interferon stimulation

O Moiseeva, FA Mallette… - Molecular biology of …, 2006 - Am Soc Cell Biol
Interferons are cytokines with potent antiviral and antiproliferative activities. We report that
although a transient exposure to β-interferon induces a reversible cell cycle arrest, a …

Switching of EBV cycles between latent and lytic states

T Murata, T Tsurumi - Reviews in medical virology, 2014 - Wiley Online Library
The EBV is a human gamma‐herpesvirus that is associated with a variety of neoplasms.
Upon primary infection, it transiently runs a short lytic program and then predominantly …

The papillomavirus E1 helicase activates a cellular DNA damage response in viral replication foci

N Sakakibara, R Mitra, AA McBride - Journal of virology, 2011 - Am Soc Microbiol
The papillomavirus E1 and E2 proteins are essential for viral genome replication. E1 is a
helicase that unwinds the viral origin and recruits host cellular factors to replicate the viral …

The DNA damage response and immune signaling alliance: Is it good or bad? Nature decides when and where

IS Pateras, S Havaki, X Nikitopoulou, K Vougas… - Pharmacology & …, 2015 - Elsevier
The characteristic feature of healthy living organisms is the preservation of homeostasis.
Compelling evidence highlight that the DNA damage response and repair (DDR/R) and …

Regulation of Epstein–Barr virus reactivation from latency

T Murata - Microbiology and immunology, 2014 - Wiley Online Library
Abstract The Epstein–Barr virus (EBV) is a human gamma‐herpesvirus that is implicated in
various types of proliferative diseases. Upon infection, it predominantly establishes latency …

[HTML][HTML] Viral carcinogenesis: factors inducing DNA damage and virus integration

Y Chen, V Williams, M Filippova, V Filippov… - Cancers, 2014 - mdpi.com
Viruses are the causative agents of 10%–15% of human cancers worldwide. The most
common outcome for virus-induced reprogramming is genomic instability, including …