The human genome encodes 538 protein kinases that transfer a γ-phosphate group from
ATP to serine, threonine, or tyrosine residues. Many of these kinases are associated with …

With cancer incidence rates continuing to increase and occurrence of resistance in drug
treatment, there is a pressing demand to find safer and more effective anticancer strategy for …

Abstract Background The Hippo-YAP signaling pathway is altered and implicated as
oncogenic in many human cancers. However, extracellular signals that regulate the …

Resveratrol and curcumin are natural products with important therapeutic properties useful
to treat several human diseases, including cancer. In the last years, the number of studies …

BACKGROUND Epidermal growth factor (EGF) has been known to induce epithelial–
mesenchymal transition (EMT) and prostate cancer cell progression. However, a detailed …

The Hippo tumor suppressor pathway is critical for balancing cellular differentiation and
proliferation in response to cell-cell contact, mechanical signals and diffusible signals such …

Lysophosphatidic acid (LPA) is a collective name for a set of bioactive lipid species. Via six
widely distributed G protein-coupled receptors (GPCRs), LPA elicits a plethora of biological …

Ovarian cancer is the most lethal gynecological malignancy. However, effective screening
strategies have not been established and continue to be elusive. A good screening test must …

Lysophosphatidic acid (LPA) functions through activation of LPA receptors (LPARs). LPA–
LPAR signaling has been implicated in development of fibrosis. However, the role of LPA …

Hippo/YAP signaling is implicated in tumorigenesis and progression of various cancers. By
inhibiting a plethora signaling cascades, resveratrol has strong anti-tumorigenic and anti …