Artificial intelligence (AI) methods have multiplied our capabilities to extract quantitative
information from digital histopathology images. AI is expected to reduce workload for human …

The Wnt pathway is central to a host of developmental and disease-related processes. The
remarkable conservation of this intercellular signaling cascade throughout metazoan …

Recent progress in targeting KRASG12C has provided both insight and inspiration for
targeting alternative KRAS mutants. In this study, we evaluated the mechanism of action and …

Simple Summary The high lethality of colorectal cancer (CRC) is anticipated to continue in
the following decades. Early-stage CRC is entirely treatable with surgery and adjuvant …

The clinical use of molecular targeted therapy is rapidly evolving but has primarily focused
on genomic alterations. Transcriptomic analysis offers an opportunity to dissect the …

Liver metastasis, the leading cause of colorectal cancer mortality, exhibits a highly
heterogeneous and suppressive immune microenvironment. Here, we sequenced 97 …

Immune responses to cancer are highly variable, with mismatch repair-deficient (MMRd)
tumors exhibiting more anti-tumor immunity than mismatch repair-proficient (MMRp) tumors …

Wnt/β-catenin signaling has been broadly implicated in human cancers and experimental
cancer models of animals. Aberrant activation of Wnt/β-catenin signaling is tightly linked with …

To chart cell composition and cell state changes that occur during the transformation of
healthy colon to precancerous adenomas to colorectal cancer (CRC), we generated single …

Chemotherapy combined with or without targeted therapy is the fundamental treatment for
metastatic colorectal cancer (mCRC). Due to the adverse effects of chemotherapeutic drugs …