Antigenic variation as a strategy to evade the host adaptive immune response has evolved
in divergent pathogens. Antigenic variation involves restricted, and often mutually exclusive …

The primary antigenic and virulence determinant of the human malaria parasite Plasmodium
falciparum is a variant surface protein called PfEMP1. Different forms of PfEMP1 are …

The red blood cell life span (RBCS) is a crucial indicator used in clinical diagnostics,
treatment, and disease monitoring. This biomarker quantifies the duration that red blood …

The pathogenesis of severe Plasmodium falciparum malaria involves cytoadhesive
microvascular sequestration of infected erythrocytes, mediated by P. falciparum erythrocyte …

Controlled human malaria infections (CHMI) are a valuable tool to study parasite gene
expression in vivo under defined conditions. In previous studies, virulence gene expression …

Over the last few decades, novel methods have been developed to study how chromosome
positioning within the nucleus may play a role in gene regulation. Adaptation of these …

Chronic, asymptomatic malaria infections contribute substantially to disease transmission
and likely represent the most significant impediment preventing malaria elimination and …

The most severe form of malaria, caused by infection with Plasmodium falciparum parasites,
continues to be an important cause of human suffering and poverty. The P. falciparum …

The malaria parasite Plasmodium falciparum employs antigenic variation of the virulence
factor P. falciparum erythrocyte membrane protein 1 (PfEMP1) to escape adaptive immune …

T he var genes family encoding the variants of the erythrocyte membrane protein of
Plasmodium falciparum is crucial for virulence of the parasite inside host. The transcriptional …