Abstract N 6-methyladenosine (m6A) is the most abundant epigenetic modification of RNA,
and its dysregulation drives aberrant transcription and translation programs that promote …

The gut microbiota is a complex and dynamic ecosystem essential for the proper functioning
of the organism, affecting the health and disease status of the individuals. There is …

Microbiota-host interactions play critical roles in colorectal cancer (CRC) progression,
however, the underlying mechanisms remain elusive. Here, we uncover that Fusobacterium …

Abstract The N6methyladenosine (m6A) RNA methyltransferase METTL16 is an emerging
player in the RNA modification landscape of the human cell. Originally thought to be a …

N6-methyladenosine (m6A) is the most prevalent internal mRNA modification. m6A can be
installed by the methyltransferase complex and removed by demethylases, which are …

Background and aims Mouse models of colitis have been used to study the pathogenesis of
inflammatory bowel disease (IBD) and for pre-clinical development of therapeutic agents …

The gut microbiota exists throughout the full life cycle of the human body, and it has been
proven to have extensive impacts on health and disease. Accumulating evidence …

Cellular RNAs are pervasively tagged with diverse chemical moieties, collectively called
epitranscriptomic modifications. The methylation of adenosine at N6 position generates N6 …

Inflammatory bowel disease (IBD) results from a complex interplay between genetic
predisposition, environmental factors, and gut microbes. The role of N6-methyladenosine …

Objectives Coeliac disease (CD) is a complex autoimmune disorder that develops in
genetically susceptible individuals. Dietary gluten triggers an immune response for which …