Background Closed-loop artificial pancreas systems have been in development for several
years, including assessment in numerous varied outpatient clinical trials. We aimed to …

The artificial pancreas (AP), known as closed-loop control of blood glucose in diabetes, is a
system combining a glucose sensor, a control algorithm, and an insulin infusion device. AP …

ISPAD Clinical Practice Consensus Guidelines 2018: Diabetes technologies Page 1 ISPAD
CLINICAL PRACTICE CONSENSUS GUIDELINES ISPAD Clinical Practice Consensus …

In this two-part Bench to Clinic narrative, recent advances in both the preclinical and clinical
aspects of artificial pancreas (AP) development are described. In the preceding Bench …

Background In patients with type 1 diabetes who are not pregnant, closed-loop (automated)
insulin delivery can provide better glycemic control than sensor-augmented pump therapy …

Background Recent studies have shown that an artificial-pancreas system can improve
glucose control and reduce nocturnal hypoglycemia. However, it is not known whether such …

Abstract Since Banting and Best isolated insulin in the 1920s, dramatic progress has been
made in the treatment of type 1 diabetes mellitus (T1DM). However, dose titration and timely …

Problematic hypoglycemia, defined as two or more episodes per year of severe
hypoglycemia or as one episode associated with impaired awareness of hypoglycemia …

Integrated closed-loop control (CLC), combining continuous glucose monitoring (CGM) with
insulin pump (continuous subcutaneous insulin infusion [CSII]), known as artificial pancreas …

Background: The level of continuous glucose monitoring (CGM) accuracy needed for insulin
dosing using sensor values (ie, the level of accuracy permitting non-adjunct CGM use) is a …