Motile and non-motile cilia are associated with mutually-exclusive genetic disorders. Motile
cilia propel sperm or extracellular fluids, and their dysfunction causes primary ciliary …

Microtubules are hollow structures formed by the lateral association of protofilaments of α-
and β-tubulin dimers. In the cytoplasm, microtubules commonly exist in the 13-protofilament …

Abstract Background Heterotaxy (Htx) syndrome comprises a class of congenital disorders
resulting from malformations in left-right body patterning. Approximately 90% of patients with …

We previously demonstrated that PACRG plays a role in regulating dynein-driven
microtubule sliding in motile cilia. To expand our understanding of the role of PACRG in …

Cilia are microtubule-based organelles that project from nearly all mammalian cell types.
Motile cilia generate fluid flow, whereas nonmotile (primary) cilia are required for sensory …

Research question Are there genetic determinants shared by unrelated women with
unexplained recurrent early miscarriage (REM)? Design Thirty REM cases and 30 controls …

Background Severe equine asthma is a chronic inflammatory disease of the lung in horses
similar to low-Th2 late-onset asthma in humans. This study aimed to determine the utility of …

The complex waveforms characteristic of motile eukaryotic cilia and flagella are produced by
the temporally and spatially regulated action of multiple dynein subforms generating sliding …

Parkin 共调基因(PACRG) 与帕金森病相关基因Parkin 共表达, 共用一个双向启动子.
它与微管蛋白的功能关系密切, 通过微管蛋白调节鞭毛, 纤毛的运动, 参与精子发育 …

Rabbits are valuable experimental animals used to evaluate the teratogenicity of chemical
entities. If teratogenicity is recognized, it is very important to investigate the pathogenesis to …