[HTML][HTML] Tauroursodeoxycholic acid: a potential therapeutic tool in neurodegenerative diseases
K Khalaf, P Tornese, A Cocco, A Albanese - Translational …, 2022 - Springer
Most neurodegenerative disorders are diseases of protein homeostasis, with misfolded
aggregates accumulating. The neurodegenerative process is mediated by numerous …
aggregates accumulating. The neurodegenerative process is mediated by numerous …
[HTML][HTML] New approved drugs appearing in the pharmaceutical market in 2022 featuring fragments of tailor-made amino acids and fluorine
The strategic fluorination of oxidatively vulnerable sites in bioactive compounds is a
relatively recent, widely used approach allowing us to modulate the stability, bio-absorption …
relatively recent, widely used approach allowing us to modulate the stability, bio-absorption …
A non-canonical cGAS–STING–PERK pathway facilitates the translational program critical for senescence and organ fibrosis
D Zhang, Y Liu, Y Zhu, Q Zhang, H Guan, S Liu… - Nature cell …, 2022 - nature.com
Innate DNA sensing via the cyclic GMP-AMP synthase–stimulator of interferon genes (cGAS–
STING) mechanism surveys microbial invasion and cellular damage and thus participates in …
STING) mechanism surveys microbial invasion and cellular damage and thus participates in …
Long‐term survival of participants in the CENTAUR trial of sodium phenylbutyrate‐taurursodiol in amyotrophic lateral sclerosis
An orally administered, fixed‐dose coformulation of sodium phenylbutyrate‐taurursodiol (PB‐
TURSO) significantly slowed functional decline in a randomized, placebo‐controlled, phase …
TURSO) significantly slowed functional decline in a randomized, placebo‐controlled, phase …
Therapeutic targeting of ALS pathways: Refocusing an incomplete picture
NJ Maragakis, M de Carvalho… - Annals of Clinical and …, 2023 - Wiley Online Library
Numerous potential amyotrophic lateral sclerosis (ALS)‐relevant pathways have been
hypothesized and studied preclinically, with subsequent translation to clinical trial. However …
hypothesized and studied preclinically, with subsequent translation to clinical trial. However …
[HTML][HTML] Status of ALS treatment, insights into therapeutic challenges and dilemmas
M Khamaysa, PF Pradat - Journal of Personalized Medicine, 2022 - mdpi.com
Amyotrophic lateral sclerosis (ALS) is an extremely heterogeneous disease of motor
neurons that eventually leads to death. Despite impressive advances in understanding the …
neurons that eventually leads to death. Despite impressive advances in understanding the …
[HTML][HTML] The role of PERK in understanding development of neurodegenerative diseases
GD Smedley, KE Walker, SH Yuan - International journal of molecular …, 2021 - mdpi.com
Neurodegenerative diseases are an ever-increasing problem for the rapidly aging
population. Despite this, our understanding of how these neurodegenerative diseases …
population. Despite this, our understanding of how these neurodegenerative diseases …
Endoplasmic reticulum stress in the dorsal root ganglia regulates large‐conductance potassium channels and contributes to pain in a model of multiple sclerosis
MS Yousuf, S Samtleben, SM Lamothe… - The FASEB …, 2020 - Wiley Online Library
Neuropathic pain is a common symptom of multiple sclerosis (MS) and current treatment
options are ineffective. In this study, we investigated whether endoplasmic reticulum (ER) …
options are ineffective. In this study, we investigated whether endoplasmic reticulum (ER) …
Pristimerin synergistically sensitizes conditionally reprogrammed patient derived-primary hepatocellular carcinoma cells to sorafenib through endoplasmic reticulum …
Y Tang, J Chen, J Li, Y Zheng, X Zhong, S Huang… - Phytomedicine, 2021 - Elsevier
Background Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-
associated mortality worldwide. Sorafenib (SORA), as a first-line therapeutic drug, has been …
associated mortality worldwide. Sorafenib (SORA), as a first-line therapeutic drug, has been …
4-Phenylbutyrate restored γ-aminobutyric acid uptake and reduced seizures in SLC6A1 patient variant-bearing cell and mouse models
G Nwosu, F Mermer, C Flamm, S Poliquin… - Brain …, 2022 - academic.oup.com
We have studied the molecular mechanisms of variants in solute carrier Family 6 Member 1
associated with neurodevelopmental disorders, including various epilepsy syndromes …
associated with neurodevelopmental disorders, including various epilepsy syndromes …