Baclofen, β-(4-chlorophenyl)-γ-aminobutyric acid, holds a unique position in neuroscience,
remaining the only US Food and Drug Administration (FDA) approved GABAB agonist …

This review addresses some promising areas of chemistry of nitro compounds extensively
developed in recent years in Russia (particularly at the ND Zelinsky Institute of Organic …

The two-step flow asymmetric synthesis of chiral γ-nitrobutyric acids as key intermediates of
the GABA analogues baclofen, phenibut, and fluorophenibut is reported on a multigram …

We report a catalytic asymmetric protocol for the preparation of chiral pyrrolidinones
proceeding via a radical pathway. The chemistry exploits the combination of photoredox …

Asymmetric access to γ‐lactams is achieved via a cyclobutanone ring expansion using
widely available (1S, 2R)‐1‐amino‐2‐indanol for chiral induction. Mechanistic analysis of …

A Rh/bisphosphine-thiourea (ZhaoPhos) catalytic system has been identified for the
straightforward asymmetric synthesis of chiral γ-lactams. A variety of NH free α, β …

A mirror‐image strategy, that is, symmetry analysis of the substrate‐binding pocket, was
applied to identify two key amino acid residues W170 and V198 that possibly modulate the …

Baclofen is a drug currently sold in a racemic form, despite R-baclofen having far higher
pharmacological activity than S-baclofen. The objective of this study is to find new cocrystals …

The iridium‐catalyzed asymmetric hydrogenation of several N‐sulfonyl allyl amines is
reported. All substrates can be easily obtained by the Ir‐catalyzed isomerization of N …

The iridium-catalyzed asymmetric hydrogenation of 2-aryl allyl phthalimides to afford
enantioenriched β-aryl-β-methyl amines is presented. Recently developed Ir-MaxPHOX …