Replication stress (RS) is a characteristic state of cancer cells as they tend to exchange
precision of replication for fast proliferation and increased genomic instability. To overcome …

Objective: To describe the mechanism of cyclin-dependent kinase (CDK) 4/6 inhibitors,
mechanisms of resistance, and summarize various clinical trials used to determine the …

Several approaches have been used in an attempt to simplify and codify the events that lead
to adverse effects of chemicals including systems biology,'omics, in vitro assays and …

Every type of cell in an animal maintains a specific size, which likely contributes to its ability
to perform its physiological functions. While some cell size control mechanisms are …

Cell division is obligatory to tumor growth. However, both cancer cells and noncancer cells
in tumors can be found in distinct stages of the cell cycle, which may inform the growth …