It is well known that separate domains with different lipid compositions can exist in
liposomes containing mixtures of different phospholipids. The question of whether cellular …

Cell motility is central to tissue homeostasis in health and disease, and there is hardly any
cell in the body that is not motile at a given point in its life cycle. Important physiological …

Lipid rafts are cholesterol‐and sphingolipid‐enriched specialized membrane domains within
the plasma membrane. Lipid rafts regulate the density and activity of signal receptors by …

Cholesterol/sphingolipid microdomains (lipid rafts) in the membrane are involved in protein
trafficking, formation of signaling complexes, and regulation of actin cytoskeleton. Here, we …

Ceramide, the precursor of all complex sphingolipids, is a potent signaling molecule that
mediates key events of cellular pathophysiology. In the nervous system, the sphingolipid …

CC chemokine receptor 5 (CCR5) is a seven-transmembrane, G protein-coupled receptor
(GPCR) which regulates trafficking and effector functions of memory/effector T-lymphocytes …

Throughout evolution, organisms have developed immune-surveillance networks to protect
themselves from potential pathogens. At the cellular level, the signalling events that regulate …

The ideal nonviral vector delivers its nucleic acid cargo to a specific intracellular target.
Vectors enter cells mainly through endocytosis and are distributed to various intracellular …

A broad array of biological responses, including cell polarization, movement, immune and
inflammatory responses, and prevention of HIV-1 infection, are triggered by the chemokines …

Lymphocyte traffic is required to maintain homeostasis and perform appropriate
immunological reactions. To migrate into inflamed tissues, lymphocytes must acquire spatial …