Defining physiological normoxia for improved translation of cell physiology to animal models and humans
TP Keeley, GE Mann - Physiological reviews, 2019 - journals.physiology.org
The extensive oxygen gradient between the air we breathe (Po2~ 21 kPa) and its ultimate
distribution within mitochondria (as low as~ 0.5–1 kPa) is testament to the efforts expended …
distribution within mitochondria (as low as~ 0.5–1 kPa) is testament to the efforts expended …
Hyperpolarized 129Xe MRI of the human lung
JP Mugler III, TA Altes - Journal of Magnetic Resonance …, 2013 - Wiley Online Library
By permitting direct visualization of the airspaces of the lung, magnetic resonance imaging
(MRI) using hyperpolarized gases provides unique strategies for evaluating pulmonary …
(MRI) using hyperpolarized gases provides unique strategies for evaluating pulmonary …
[HTML][HTML] Analysis of cancer metabolism by imaging hyperpolarized nuclei: prospects for translation to clinical research
A major challenge in cancer biology is to monitor and understand cancer metabolism in vivo
with the goal of improved diagnosis and perhaps therapy. Because of the complexity of …
with the goal of improved diagnosis and perhaps therapy. Because of the complexity of …
Imaging of lung function using hyperpolarized helium‐3 magnetic resonance imaging: review of current and emerging translational methods and applications
During the past several years there has been extensive development and application of
hyperpolarized helium‐3 (HP 3He) magnetic resonance imaging (MRI) in clinical respiratory …
hyperpolarized helium‐3 (HP 3He) magnetic resonance imaging (MRI) in clinical respiratory …
Functional imaging of the lungs with gas agents
This review focuses on the state‐of‐the‐art of the three major classes of gas contrast agents
used in magnetic resonance imaging (MRI)—hyperpolarized (HP) gas, molecular oxygen …
used in magnetic resonance imaging (MRI)—hyperpolarized (HP) gas, molecular oxygen …
The difference in ventilation heterogeneity between asthmatic and healthy subjects quantified using hyperpolarized 3He MRI
In this pilot study, algorithms for quantitatively evaluating the distribution and heterogeneity
of human ventilation imaged with hyperpolarized (HP) 3He MRI were developed for the goal …
of human ventilation imaged with hyperpolarized (HP) 3He MRI were developed for the goal …
Functional lung imaging using hyperpolarized gas MRI
The noninvasive assessment of lung function using imaging is increasingly of interest for the
study of lung diseases, including chronic obstructive pulmonary disease (COPD) and …
study of lung diseases, including chronic obstructive pulmonary disease (COPD) and …
Quantitative imaging metrics for the assessment of pulmonary pathophysiology: an official American Thoracic Society and Fleischner Society joint workshop report
Multiple thoracic imaging modalities have been developed to link structure to function in the
diagnosis and monitoring of lung disease. Volumetric computed tomography (CT) renders …
diagnosis and monitoring of lung disease. Volumetric computed tomography (CT) renders …
Magnetic resonance imaging with hyperpolarized agents: methods and applications
In the past decade, hyperpolarized (HP) contrast agents have been under active
development for MRI applications to address the twin challenges of functional and …
development for MRI applications to address the twin challenges of functional and …
Overview of MRI for pulmonary functional imaging
Y Ohno, S Hanamatsu, Y Obama, T Ueda… - The British Journal of …, 2022 - academic.oup.com
Morphological evaluation of the lung is important in the clinical evaluation of pulmonary
diseases. However, the disease process, especially in its early phases, may primarily result …
diseases. However, the disease process, especially in its early phases, may primarily result …