Teaching an old dogma new tricks: twenty years of Shc adaptor signalling
Shc (Src homology and collagen homology) proteins are considered prototypical signalling
adaptors in mammalian cells. Consisting of four unique members, ShcA, B, C and D, and …
adaptors in mammalian cells. Consisting of four unique members, ShcA, B, C and D, and …
Positive and negative regulation of antigen receptor signaling by the Shc family of protein adapters
F Finetti, MT Savino, CT Baldari - Immunological reviews, 2009 - Wiley Online Library
The Shc adapter family includes four members that are expressed as multiple isoforms and
participate in signaling by a variety of cell‐surface receptors. The biological relevance of Shc …
participate in signaling by a variety of cell‐surface receptors. The biological relevance of Shc …
[HTML][HTML] Insights into the Shc family of adaptor proteins
SBM Ahmed, SA Prigent - Journal of molecular signaling, 2017 - ncbi.nlm.nih.gov
The Shc family of adaptor proteins is a group of proteins that lacks intrinsic enzymatic
activity. Instead, Shc proteins possess various domains that allow them to recruit different …
activity. Instead, Shc proteins possess various domains that allow them to recruit different …
Rai is a new regulator of neural progenitor migration and glioblastoma invasion
B Ortensi, D Osti, S Pellegatta, F Pisati, P Brescia… - Stem …, 2012 - academic.oup.com
The invasive nature of glioblastoma (GBM) is one important reason for treatment failure.
GBM stem/progenitor cells retain the migratory ability of normal neural stem/progenitor cells …
GBM stem/progenitor cells retain the migratory ability of normal neural stem/progenitor cells …
[HTML][HTML] Differential proteomic analysis of astrocytes and astrocytes-derived extracellular vesicles from control and rai knockout mice: insights into the mechanisms of …
T Montecchi, E Shaba, D De Tommaso… - International Journal of …, 2021 - mdpi.com
Reactive astrocytes are a hallmark of neurodegenerative disease including multiple
sclerosis. It is widely accepted that astrocytes may adopt alternative phenotypes depending …
sclerosis. It is widely accepted that astrocytes may adopt alternative phenotypes depending …
[HTML][HTML] A syndrome featuring developmental disorder of the nervous system induced by a novel mutation in the TCF20 gene, rarely concurrent immune disorders: a …
S Huang, J Xu, Y Li, W Mo, X Lin, Y Wang… - Frontiers in …, 2023 - frontiersin.org
Background: The expression of TCF20 is the most widespread in brain tissue. TCF20
depletion or mutation can affect the proliferation and differentiation of embryonic neurons …
depletion or mutation can affect the proliferation and differentiation of embryonic neurons …
[HTML][HTML] Human colorectal cancer: upregulation of the adaptor protein Rai in TILs leads to cell dysfunction by sustaining GSK-3 activation and PD-1 expression
T Montecchi, G Nannini, D De Tommaso… - Cancer Immunology …, 2024 - Springer
Background The immunosuppressive tumor microenvironment (TME) of colorectal cancer
(CRC) is a major hurdle for immune checkpoint inhibitor-based therapies. Hence …
(CRC) is a major hurdle for immune checkpoint inhibitor-based therapies. Hence …
Insights into the genetic basis and immunopathogenesis of systemic lupus erythematosus from the study of mouse models
YH Cheung, C Loh, E Pau, J Kim, J Wither - Seminars in immunology, 2009 - Elsevier
Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease characterized by
production of autoantibodies directed against nuclear antigens resulting in formation of …
production of autoantibodies directed against nuclear antigens resulting in formation of …
Expression patterns of ShcD and Shc family adaptor proteins during mouse embryonic development
SP Hawley, MKB Wills, AJ Rabalski… - Developmental …, 2011 - Wiley Online Library
The Src homology and collagen (Shc) proteins function as molecular adaptors in signaling
pathways mediated by a variety of cell surface receptors. Of the four mammalian Shc …
pathways mediated by a variety of cell surface receptors. Of the four mammalian Shc …
[HTML][HTML] AT cell suppressive circuitry mediated by CD39 and regulated by ShcC/Rai is induced in astrocytes by encephalitogenic T cells
C Ulivieri, D De Tommaso, F Finetti, B Ortensi… - Frontiers in …, 2019 - frontiersin.org
Multiple sclerosis is an autoimmune disease caused by autoreactive immune cell infiltration
into the central nervous system leading to inflammation, demyelination, and neuronal loss …
into the central nervous system leading to inflammation, demyelination, and neuronal loss …