[HTML][HTML] Protective mechanisms and current clinical evidence of hypothermic oxygenated machine perfusion (HOPE) in preventing post-transplant cholangiopathy

A Schlegel, RJ Porte, P Dutkowski - Journal of Hepatology, 2022 - Elsevier
The development of cholangiopathies after liver transplantation impacts on the quality and
duration of graft and patient survival, contributing to higher costs as numerous interventions …

[HTML][HTML] Machine perfusion of donor livers for transplantation: a proposal for standardized nomenclature and reporting guidelines

SA Karangwa, P Dutkowski, P Fontes, PJ Friend… - American journal of …, 2016 - Elsevier
With increasing demand for donor organs for transplantation, machine perfusion (MP)
promises to be a beneficial alternative preservation method for donor livers, particularly …

[HTML][HTML] Abdominal normothermic regional perfusion in controlled donation after circulatory determination of death liver transplantation: outcomes and risk factors for …

AJ Hessheimer, G de la Rosa, M Gastaca… - American Journal of …, 2022 - Elsevier
Postmortem normothermic regional perfusion (NRP) is a rising preservation strategy in
controlled donation after circulatory determination of death (cDCD). Herein, we present …

[HTML][HTML] Observations on the ex situ perfusion of livers for transplantation

CJE Watson, V Kosmoliaptsis, C Pley, L Randle… - American journal of …, 2018 - Elsevier
Normothermic ex situ liver perfusion might allow viability assessment of livers before
transplantation. Perfusion characteristics were studied in 47 liver perfusions, of which 22 …

Transplantation of high-risk donor livers after ex situ resuscitation and assessment using combined hypo-and normothermic machine perfusion: a prospective clinical …

OB van Leeuwen, Y de Vries, M Fujiyoshi… - Annals of …, 2019 - journals.lww.com
Objective: The aim of this study was to evaluate sequential hypothermic and normothermic
machine perfusion (NMP) as a tool to resuscitate and assess viability of initially declined …

[HTML][HTML] In situ normothermic perfusion of livers in controlled circulatory death donation may prevent ischemic cholangiopathy and improve graft survival

CJE Watson, F Hunt, S Messer, I Currie, S Large… - American Journal of …, 2019 - Elsevier
Livers from controlled donation after circulatory death (DCD) donors suffer a higher
incidence of nonfunction, poor function, and ischemic cholangiopathy. In situ normothermic …

Transplantation of Declined Liver Allografts Following Normothermic Ex‐Situ Evaluation

H Mergental, M Perera, RW Laing… - American journal of …, 2016 - Wiley Online Library
The demand for liver transplantation (LT) exceeds supply, with rising waiting list mortality.
Utilization of high‐risk organs is low and a substantial number of procured livers are …

Biliary bicarbonate, pH, and glucose are suitable biomarkers of biliary viability during ex situ normothermic machine perfusion of human donor livers

APM Matton, Y de Vries, LC Burlage, R van Rijn… - …, 2019 - journals.lww.com
Background. Ex situ normothermic machine perfusion (NMP) can be used to assess viability
of suboptimal donor livers before implantation. Our aim was to assess the diagnostic …

Bile proteome reveals biliary regeneration during normothermic preservation of human donor livers

AM Thorne, JC Wolters, B Lascaris… - Nature …, 2023 - nature.com
Normothermic machine perfusion (NMP) after static cold storage is increasingly used for
preservation and assessment of human donor livers prior to transplantation. Biliary viability …

[PDF][PDF] Pilot, open, randomized, prospective trial for normothermic machine perfusion evaluation in liver transplantation from older donors

D Ghinolfi, E Rreka, V De Tata, M Franzini… - Liver …, 2019 - Wiley Online Library
Ex situ normothermic machine perfusion (NMP) might minimize ischemia/reperfusion injury
(IRI) of liver grafts. In this study, 20 primary liver transplantation recipients of older grafts (≥ …