Cancer is one of the main causes of death worldwide. Despite the significant development of
methods of cancer healing during the past decades, chemotherapy still remains the main …

DNA damage can alter nucleotide sequences and lead to expression of dysfunctional
proteins that impact normal cellular physiology. Sources of DNA damage can be …

The main goal of chemotherapeutic drugs is to induce massive cell death in tumors.
Cisplatin is an antitumor drug widely used to treat several types of cancer. Despite its …

Platinum (Pt) resistance in cancer almost inevitably occurs during clinical Pt-based
chemotherapy. The spontaneous nucleotide-excision repair of cancer cells is a …

The hallmarks of cancer described by Hanahan and Weinberg have proved seminal in our
understanding of cancer's common traits and in rational drug design. Not free of critique and …

Defects in DNA repair can result in oncogenic genomic instability. Cancers occurring from
DNA repair defects were once thought to be limited to rare inherited mutations (such as …

PARP inhibitors have highly significant effects on BRCA mutant cells, allowing targeted
therapy of triple-negative breast cancer (TNBC). However, some TBNC patients lack BRCA …

Abstract Reduction-oxidation factor 1-apurinic/apyrimidinic endonuclease (Ref-1/APE1) is a
critical node in tumor cells, both as a redox regulator of transcription factor activation and as …

Pancreatic ductal adenocarcinoma (PDAC), one of the most aggressive types of cancer, is
characterized by aberrant activity of oncogenic KRAS. A nuclease-hypersensitive GC-rich …

Combination therapy is becoming imperative for the treatment of many cancers, as it
provides a higher chance of avoiding drug resistance and tumor recurrence. Among the …