Inwardly rectifying K+ (Kir) channels allow K+ to move more easily into rather than out of the
cell. They have diverse physiological functions depending on their type and their location …

G protein-gated inwardly rectifying potassium (GIRK) channels hyperpolarize neurons in
response to activation of many different G protein-coupled receptors and thus control the …

Potassium channels are particularly important in determining the shape and duration of the
action potential, controlling the membrane potential, modulating hormone secretion …

G protein-gated inwardly rectifying potassium channels (Kir3/GirK) are important for
maintaining resting membrane potential, cell excitability and inhibitory neurotransmission …

The rewarding effect of drugs of abuse is mediated by activation of the mesolimbic
dopamine system, which is inhibited by putative anti-craving compounds. Interestingly …

Parkinson's disease (PD) is a neurodegenerative disorder characterized by selective loss of
dopaminergic neurons in the substantia nigra pars compacta (SNpc) region of the midbrain …

The α subunit of a prototypical heterotrimeric GTP-binding protein (G protein), which is
encoded by a single gene (GPA1) in Arabidopsis, is a modulator of plant cell proliferation …

Acute opioid administration causes hyperpolarization of locus ceruleus (LC) neurons. A G-
protein-gated, inwardly rectifying potassium (GIRK/KG) conductance and a cAMP …

The analgesia produced by inhibitory G protein-coupled receptor agonists involves
coordinated postsynaptic inhibition via G protein-coupled inwardly rectifying potassium …

Agonists of GABAB receptors exert a bi-directional effect on the activity of dopamine (DA)
neurons of the ventral tegmental area, which can be explained by the fact that coupling …