Objective Anti–citrullinated protein antibodies (ACPAs) are a hallmark of seropositive
rheumatoid arthritis (RA). Yet, the precise disease‐relevant autoantigens that are targeted …

Dating to the discovery of the Lupus Erythematosus (LE) cell in 1948, there has been a
dramatic growth in the discovery of unique autoantibodies and their cognate targets, all of …

Background Rheumatoid arthritis (RA) is an autoimmune disease caused by a variety of
unknown factors. It mainly occurs in the small joints of hands and feet, leading to cartilage …

Seropositive rheumatoid arthritis (RA) is characterized by the presence of rheumatoid factor
(RF) and anti-citrullinated protein autoantibodies (ACPA) with different fine-specificities. Yet …

Rheumatoid factors (RFs), polyreactive antibodies canonically known to bind two
conformational epitopes of IgG Fc, are a hallmark of rheumatoid arthritis but also can arise in …

Objective Rheumatoid arthritis (RA) patients often develop rheumatoid factors (RFs),
antibodies that bind IgG Fc, and anti–modified protein antibodies (AMPAs), multireactive …

Introduction Anti-citrullinated protein antibodies (ACPAs) are a hallmark of rheumatoid
arthritis, but the sources of citrullinated antigens as well as which peptidylarginine …

Background The disability rate associated with rheumatoid arthritis (RA) ranks high among
inflammatory joint diseases. However, the cause and potential molecular events are as yet …

A/B testing, a widely used form of Randomized Controlled Trial (RCT), is a fundamental tool
in business data analysis and experimental design. However, despite its intent to maintain …

The majority of patients diagnosed with rheumatoid arthritis (RA) have developed
autoantibodies against neoepitopes in proteins that have undergone post-translational …