Vascular endothelial cells form the inner layer of blood vessels where they have a key role
in the development and maintenance of the functional circulatory system and provide …

There are two vascular networks in mammals that coordinately function as the main supply
and drainage systems of the body. The blood vasculature carries oxygen, nutrients …

Vascular networks form, remodel, and mature under the influence of both fluid shear stress
(FSS) and soluble factors. Physiological FSS promotes and maintains vascular stability via …

Endothelial cell (EC) sensing of wall fluid shear stress (FSS) from blood flow governs vessel
remodeling to maintain FSS at a specific magnitude or set point in healthy vessels. Low FSS …

Vessel formation and differentiation to a proper hierarchical vasculature requires a
coordinated effort from endothelial and mural cells. Over the last decade Notch was …

BACKGROUND: Mature endothelial cells (ECs) are heterogeneous, with subtypes defined
by tissue origin and position within the vascular bed (ie, artery, capillary, vein, and …

Cell segregation allows the compartmentalization of cells with similar fates during
morphogenesis, which can be enhanced by cell fate plasticity in response to local molecular …

Myocardial injury as induced by myocardial infarction results in tissue ischemia, which
critically incepts cardiomyocyte death. Endothelial cells play a crucial role in restoring …

Simple Summary Nowadays, the upfront treatment for patients facing a diagnosis of
advanced luminal breast cancer (BC) is a combination of endocrine therapy (ET) with an …

Phosphoinositide 3-kinases (PI3Ks) phosphorylate intracellular inositol lipids to regulate
signaling and intracellular vesicular trafficking. Mammals have eight PI3K isoforms, of which …