The contribution of microglia to neuroinflammation in Parkinson's disease
K Badanjak, S Fixemer, S Smajić, A Skupin… - International Journal of …, 2021 - mdpi.com
With the world's population ageing, the incidence of Parkinson's disease (PD) is on the rise.
In recent years, inflammatory processes have emerged as prominent contributors to the …
In recent years, inflammatory processes have emerged as prominent contributors to the …
Glatiramer acetate immunomodulation: evidence of neuroprotection and cognitive preservation
A Kasindi, DT Fuchs, Y Koronyo, A Rentsendorj… - Cells, 2022 - mdpi.com
Novel, neuroprotective uses of Copaxone (generic name: glatiramer acetate—GA) are being
examined, primarily in neurological conditions involving cognitive decline. GA is a well …
examined, primarily in neurological conditions involving cognitive decline. GA is a well …
Pathogenesis of α-Synuclein in Parkinson's Disease: From a Neuron-Glia Crosstalk Perspective
S Yi, L Wang, H Wang, MS Ho, S Zhang - International Journal of …, 2022 - mdpi.com
Parkinson's disease (PD) is a progressive neurodegenerative disorder. The classical
behavioral defects of PD patients involve motor symptoms such as bradykinesia, tremor, and …
behavioral defects of PD patients involve motor symptoms such as bradykinesia, tremor, and …
Immunosenescence as a convergence pathway in neurodegeneration
L Mohapatra, D Mishra, AS Tripathi… - International …, 2023 - Elsevier
Immunity refers to the body's defense mechanism to protect itself against illness or to
produce antibodies against pathogens. Senescence is a cellular phenomenon that …
produce antibodies against pathogens. Senescence is a cellular phenomenon that …
T lymphocytes in Parkinson's disease
E Contaldi, L Magistrelli, C Comi - Journal of Parkinson's …, 2022 - content.iospress.com
T cells are key mediators of both humoral and cellular adaptive immune responses, and
their role in Parkinson's disease (PD) is being increasingly recognized. Several lines of …
their role in Parkinson's disease (PD) is being increasingly recognized. Several lines of …
Repurposing immunomodulatory Imide Drugs (IMiDs) in neuropsychiatric and neurodegenerative disorders
YJ Jung, D Tweedie, MT Scerba, DS Kim… - Frontiers in …, 2021 - frontiersin.org
Neuroinflammation represents a common trait in the pathology and progression of the major
psychiatric and neurodegenerative disorders. Neuropsychiatric disorders have emerged as …
psychiatric and neurodegenerative disorders. Neuropsychiatric disorders have emerged as …
The neuroprotective effects of isoquercitrin purified from apple pomace by high-speed countercurrent chromatography in the MPTP acute mouse model of Parkinson's …
Parkinson's disease is the second most common neurodegenerative disease. Researchers
have shown that oxidative stress and apoptosis play an important role in the Parkinson's …
have shown that oxidative stress and apoptosis play an important role in the Parkinson's …
[HTML][HTML] Evidence of inflammation in Parkinson's disease and its contribution to synucleinopathy
TT Lai, YJ Kim, H Ma, YE Kim - Journal of Movement Disorders, 2022 - ncbi.nlm.nih.gov
Accumulation of alpha-synuclein (αSyn) protein in neurons is a renowned pathological
hallmark of Parkinson's disease (PD). In addition, accumulating evidence indicates that …
hallmark of Parkinson's disease (PD). In addition, accumulating evidence indicates that …
Recovery of motor function is associated with rescue of glutamate biomarkers in the striatum and motor cortex following treatment with Mucuna pruriens in a murine …
T Denne, LC Winfrey, C Moore, C Whitner… - Molecular and Cellular …, 2023 - Elsevier
There is growing interest in the use of natural products for the treatment of Parkinson's
disease (PD). Mucuna pruriens has been used in the treatment of humans with PD. The goal …
disease (PD). Mucuna pruriens has been used in the treatment of humans with PD. The goal …
Differential ultrastructural alterations in the Vglut2 glutamatergic input to the substantia nigra pars compacta/pars reticulata following nigrostriatal dopamine loss in a …
C Moore, M Xu, JK Bohlen… - European Journal of …, 2021 - Wiley Online Library
Loss of nigrostriatal dopamine (DA) in Parkinson's disease results in over‐
activation/bursting of the subthalamic nucleus (STN). The STN projects to the substantia …
activation/bursting of the subthalamic nucleus (STN). The STN projects to the substantia …