Acetylcholine (ACh) is one of the most important neurotransmitters in the central cholinergic
system; it specifically binds to muscarinic and nicotinic receptors and is degraded by …

Alzheimer's disease (AD) remains a major cause of morbidity and mortality worldwide, and
despite extensive research, only a few drugs are available for management of the disease …

Exposure to addictive substances impairs flexible decision making. Cognitive flexibility is
mediated by striatal cholinergic interneurons (CINs). However, how chronic alcohol drinking …

The M1 and M4 muscarinic acetylcholine receptors (mAChRs) are highly pursued drug
targets for neurological diseases, in particular for Alzheimer's disease and schizophrenia …

Emerging evidence suggests muscarinic acetylcholine receptors represent novel targets to
treat alcohol use disorder. In this review, we draw from literature across medicinal chemistry …

Cholinergic regulation of dopamine (DA) signaling has significant implications for numerous
disorders, including schizophrenia, substance use disorders, and mood-related disorders …

Introduction Impulse control disorders (eg pathological gambling, hypersexuality) may
develop as adverse reactions to drugs. Pathogenetic hypotheses have mainly focused on …

Cocaine drastically elevates dopamine (DA) levels in the striatum, a brain region that is
critical to the psychomotor and rewarding properties of the drug. DA signaling regulates …

Background Alcohol use disorder (AUD) is a major socioeconomic burden on society, and
current pharmacotherapeutic treatment options are inadequate. Aberrant alcohol use and …

Inhibitory control is a key executive function that limits unnecessary thoughts and actions,
enabling an organism to appropriately execute goal-driven behaviors. The efficiency of this …