Valproic acid is a widely-used first-generation antiepileptic drug, prescribed predominantly
in epilepsy and psychiatric disorders. VPA has good efficacy and pharmacoeconomic …

Valproic acid, a branching short chain fatty acid, is a popular drug to treat epilepsy and acts
as a mood-stabilizing drug. The obstruction of ion channels and Gamma Amino Butyrate …

Tacrolimus was discovered in 1984 and entered clinical use shortly thereafter, contributing
to successful solid organ transplantation across the globe. In this review, we cover …

A number of metabolic disorders that affect the central nervous system can present in
childhood, adolescence or adulthood as a phenocopy of a major psychiatric syndrome such …

Drug‐nutrient interactions are defined as physical, chemical, physiologic, or
pathophysiologic relationships between a drug and a nutrient. The causes of most clinically …

Mood stabilizers such as lithium and anticonvulsants are still standard-of-care for the acute
and long-term treatment of bipolar disorder (BD). This systematic review aimed to assess the …

Valproic acid (VPA), or sodium valproate, is a commonly used medication for seizure
disorders, migraines, and mental illness. Although VPA is relatively safe, it still has several …

Purpose The purpose was to describe the use of valproate therapy for agitation in critically ill
patients, examine its safety, and describe its relationship with agitation and delirium …

Abstract Introduction: Valproic acid (VPA)–induced hyperammonemia poses several clinical
challenges in psychiatric medicine. The reported incidence of this adverse effect varies …

Objective Valproic acid (VPA)-induced hyperammonemia (VIH), is an increase in blood
ammonia levels without any alteration of hepatic enzymes, which can occur during VPA …