The role of short-chain fatty acids in intestinal barrier function, inflammation, oxidative stress, and colonic carcinogenesis
P Liu, Y Wang, G Yang, Q Zhang, L Meng, Y Xin… - Pharmacological …, 2021 - Elsevier
Short-chain fatty acids (SCFAs), mainly including acetate, propionate, and butyrate, are
metabolites produced during the bacterial fermentation of dietary fiber in the intestinal tract …
metabolites produced during the bacterial fermentation of dietary fiber in the intestinal tract …
Functions and mechanisms of non-histone protein acetylation
N ε-lysine acetylation was discovered more than half a century ago as a post-translational
modification of histones and has been extensively studied in the context of transcription …
modification of histones and has been extensively studied in the context of transcription …
Proteogenomic characterization reveals therapeutic vulnerabilities in lung adenocarcinoma
To explore the biology of lung adenocarcinoma (LUAD) and identify new therapeutic
opportunities, we performed comprehensive proteogenomic characterization of 110 tumors …
opportunities, we performed comprehensive proteogenomic characterization of 110 tumors …
Acetylation in the regulation of autophagy
Y Xu, W Wan - Autophagy, 2023 - Taylor & Francis
Post-translational modifications, such as phosphorylation, ubiquitination and acetylation,
play crucial roles in the regulation of autophagy. Acetylation has emerged as an important …
play crucial roles in the regulation of autophagy. Acetylation has emerged as an important …
The transcription factor activity gradient (TAG) model: contemplating a contact-independent mechanism for enhancer–promoter communication
How distal cis-regulatory elements (eg, enhancers) communicate with promoters remains an
unresolved question of fundamental importance. Although transcription factors and cofactors …
unresolved question of fundamental importance. Although transcription factors and cofactors …
Discovery of a selective catalytic p300/CBP inhibitor that targets lineage-specific tumours
LM Lasko, CG Jakob, RP Edalji, W Qiu, D Montgomery… - Nature, 2017 - nature.com
The dynamic and reversible acetylation of proteins, catalysed by histone acetyltransferases
(HATs) and histone deacetylases (HDACs), is a major epigenetic regulatory mechanism of …
(HATs) and histone deacetylases (HDACs), is a major epigenetic regulatory mechanism of …
[HTML][HTML] Histone acetyltransferases CBP/p300 in tumorigenesis and CBP/p300 inhibitors as promising novel anticancer agents
Q Chen, B Yang, X Liu, XD Zhang, L Zhang, T Liu - Theranostics, 2022 - ncbi.nlm.nih.gov
The histone acetyltransferases CBP and p300, often referred to as CBP/p300 due to their
sequence homology and functional overlap and co-operation, are emerging as critical …
sequence homology and functional overlap and co-operation, are emerging as critical …
[HTML][HTML] The world of protein acetylation
Acetylation is one of the major post-translational protein modifications in the cell, with
manifold effects on the protein level as well as on the metabolome level. The acetyl group …
manifold effects on the protein level as well as on the metabolome level. The acetyl group …
Time-resolved analysis reveals rapid dynamics and broad scope of the CBP/p300 acetylome
The acetyltransferases CBP and p300 are multifunctional transcriptional co-activators. Here,
we combined quantitative proteomics with CBP/p300-specific catalytic inhibitors …
we combined quantitative proteomics with CBP/p300-specific catalytic inhibitors …
The growing landscape of lysine acetylation links metabolism and cell signalling
Lysine acetylation is a conserved protein post-translational modification that links acetyl-
coenzyme A metabolism and cellular signalling. Recent advances in the identification and …
coenzyme A metabolism and cellular signalling. Recent advances in the identification and …