Hypoxia, a targetable culprit to counter pancreatic cancer resistance to therapy
Simple Summary Hypoxia is a key feature of the tumor microenvironment involved in the
pathogenesis of pancreatic ductal adenocarcinoma (PDAC). In this review we will highlight …
pathogenesis of pancreatic ductal adenocarcinoma (PDAC). In this review we will highlight …
Role of MRI-based functional imaging in improving the therapeutic index of radiotherapy in cancer treatment
M Li, Q Zhang, K Yang - Frontiers in Oncology, 2021 - frontiersin.org
Advances in radiation technology, such as intensity-modulated radiation therapy (IMRT),
have largely enabled a biological dose escalation of the target volume (TV) and reduce the …
have largely enabled a biological dose escalation of the target volume (TV) and reduce the …
Improved unsupervised physics‐informed deep learning for intravoxel incoherent motion modeling and evaluation in pancreatic cancer patients
MPT Kaandorp, S Barbieri, R Klaassen… - Magnetic resonance …, 2021 - Wiley Online Library
Purpose Earlier work showed that IVIM‐NETorig, an unsupervised physics‐informed deep
neural network, was faster and more accurate than other state‐of‐the‐art intravoxel …
neural network, was faster and more accurate than other state‐of‐the‐art intravoxel …
[HTML][HTML] Deep learning DCE-MRI parameter estimation: Application in pancreatic cancer
T Ottens, S Barbieri, MR Orton, R Klaassen… - Medical image …, 2022 - Elsevier
Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) is an MRI technique
for quantifying perfusion that can be used in clinical applications for classification of tumours …
for quantifying perfusion that can be used in clinical applications for classification of tumours …
Pathological validation and prognostic potential of quantitative MRI in the characterization of pancreas cancer: preliminary experience
R Klaassen, A Steins, OJ Gurney‐Champion… - Molecular …, 2020 - Wiley Online Library
Patient stratification based on biological variation in pancreatic ductal adenocarcinoma
(PDAC) subtypes could help to improve clinical outcome. However, noninvasive assessment …
(PDAC) subtypes could help to improve clinical outcome. However, noninvasive assessment …
[HTML][HTML] Multiparameter MRI predictors of long-term survival in glioblastoma multiforme
O Stringfield, JA Arrington, SK Johnston… - …, 2019 - pmc.ncbi.nlm.nih.gov
Standard-of-care multiparameter magnetic resonance imaging (MRI) scans of the brain were
used to objectively subdivide glioblastoma multiforme (GBM) tumors into regions that …
used to objectively subdivide glioblastoma multiforme (GBM) tumors into regions that …
Extracellular volume fraction with MRI: As an alternative predictive biomarker to dynamic contrast-enhanced MRI for chemotherapy response of pancreatic ductal …
Y Fukukura, Y Kumagae, Y Fujisaki… - European journal of …, 2021 - Elsevier
Purpose To assess the feasibility of extracellular volume (ECV) fraction determined with
equilibrium contrast-enhanced MRI for prediction of treatment response to chemotherapy in …
equilibrium contrast-enhanced MRI for prediction of treatment response to chemotherapy in …
Radiotherapy respiratory motion management in hepatobiliary and pancreatic malignancies: a systematic review of patient factors influencing effectiveness of motion …
M Daly, A McWilliam, G Radhakrishna… - Acta …, 2022 - Taylor & Francis
Background The effectiveness of abdominal compression for motion management in
hepatobiliary-pancreatic (HPB) radiotherapy has not been systematically evaluated …
hepatobiliary-pancreatic (HPB) radiotherapy has not been systematically evaluated …
Accelerating mri uncertainty estimation with mask-based bayesian neural network
Z Zhang, M Genci, H Fan… - 2024 IEEE 35th …, 2024 - ieeexplore.ieee.org
Accurate and reliable Magnetic Resonance Imaging (MRI) analysis is particularly important
for adaptive radio-therapy, a recent medical advance capable of improving cancer diagnosis …
for adaptive radio-therapy, a recent medical advance capable of improving cancer diagnosis …
Phase I/II study of LDE225 in combination with gemcitabine and nab-paclitaxel in patients with metastatic pancreatic cancer
EN Pijnappel, NPM Wassenaar, OJ Gurney-Champion… - Cancers, 2021 - mdpi.com
Simple Summary One of the reasons for treatment resistance of PDAC is the desmoplastic
reaction initiating the production of large amounts of tumor stroma. LDE225 is a …
reaction initiating the production of large amounts of tumor stroma. LDE225 is a …