Extracellular vesicles (EVs) are nano-scaled vesicles released from all cell types into
extracellular fluids and specifically contain signature molecules of the original cells and …

Iron is a double-edged sword. It is vital for all that's living, yet its deficiency or overload can
be fatal. In humans, iron homeostasis is tightly regulated at both cellular and systemic levels …

Introduction: Gestational vascular complications (GVCs), including gestational hypertension
and preeclampsia, are leading causes of maternal morbidity and mortality. Elevated levels of …

Genetic mutations in the β-globin gene lead to a decrease or removal of the β-globin chain,
causing the build-up of unstable alpha-hemoglobin. This condition is referred to as beta …

Erythropoiesis is a complex, precise, and lifelong process that is essential for maintaining
normal body functions. Its strict regulation is necessary to prevent a variety of blood …

Hospital, Nanjing Medical University, Nanjing, China β-thalassemia is a hereditary disease
caused by the β-globin gene mutations. Blood transfusion, 1, 2 stem cell transplantation, 3, 4 …

Thromboembolic events are a significant clinical concern in thalassemia and
hemoglobinopathies, highlighting the need for new strategies to treat and detect these …

Who would have thought that the discovery made by researchers at Washington University
[1] and McGill University [2] almost 40 years ago would help us to fully understand the …

Thalassemia encompasses a group of inherited hemoglobin disorders characterized by
reduced or absent production of the α-or β-globin chains, leading to anemia and other …

Thalassemia is the most common monogenic disorder of red blood cells (RBCs) caused by
defects in the synthesis of globin chains. Thalassemia phenotypes have a wide spectrum of …