A review of the pangenome: how it affects our understanding of genomic variation, selection and breeding in domestic animals?
Y Gong, Y Li, X Liu, Y Ma, L Jiang - Journal of Animal Science and …, 2023 - Springer
As large-scale genomic studies have progressed, it has been revealed that a single
reference genome pattern cannot represent genetic diversity at the species level. While …
reference genome pattern cannot represent genetic diversity at the species level. While …
Transformation of animal genomics by next-generation sequencing technologies: a decade of challenges and their impact on genetic architecture
For more than a quarter of a century, sequencing technologies from Sanger's method to next-
generation high-throughput techniques have provided fascinating opportunities in the life …
generation high-throughput techniques have provided fascinating opportunities in the life …
A gene prioritization method based on a swine multi-omics knowledgebase and a deep learning model
Y Fu, J Xu, Z Tang, L Wang, D Yin, Y Fan… - Communications …, 2020 - nature.com
The analyses of multi-omics data have revealed candidate genes for objective traits.
However, they are integrated poorly, especially in non-model organisms, and they pose a …
However, they are integrated poorly, especially in non-model organisms, and they pose a …
GWAS for meat and carcass traits using imputed sequence level genotypes in pooled F2-designs in pigs
C Falker-Gieske, I Blaj, S Preuß… - G3: Genes …, 2019 - academic.oup.com
In order to gain insight into the genetic architecture of economically important traits in pigs
and to derive suitable genetic markers to improve these traits in breeding programs, many …
and to derive suitable genetic markers to improve these traits in breeding programs, many …
Analyzing super-enhancer temporal dynamics reveals potential critical enhancers and their gene regulatory networks underlying skeletal muscle development
S Zhang, C Wang, S Qin, C Chen, Y Bao… - Genome …, 2024 - genome.cshlp.org
Super-enhancers (SEs) govern the expression of genes defining cell identity. However, the
dynamic landscape of SEs and their critical constituent enhancers involved in skeletal …
dynamic landscape of SEs and their critical constituent enhancers involved in skeletal …
CRISPR/Cas9-meditated gene knockout in pigs proves that LGALS12 deficiency suppresses the proliferation and differentiation of porcine adipocytes
W Wu, Y Yin, J Huang, R Yang, Q Li, J Pan… - Biochimica et Biophysica …, 2024 - Elsevier
LGALS12, also known as galectin12, belongs to the galectin family with β-galactoside-
binding activity. We previously reported that LGALS12 is an important regulator of …
binding activity. We previously reported that LGALS12 is an important regulator of …
Mapping and functional characterization of structural variation in 1060 pig genomes
Abstract Background Structural variations (SVs) have significant impacts on complex
phenotypes by rearranging large amounts of DNA sequence. Results We present a …
phenotypes by rearranging large amounts of DNA sequence. Results We present a …
Identification of body size determination related candidate genes in domestic pig using genome-wide selection signal analysis
B Pan, H Long, Y Yuan, H Zhang, Y Peng, D Zhou… - Animals, 2022 - mdpi.com
Simple Summary In this study, the pairwise fixation index (FST) and π ratio (case/control)
genetic parameters were used to identify the genes that influence the body size of pigs and …
genetic parameters were used to identify the genes that influence the body size of pigs and …
Genetic introgression from commercial European pigs to the indigenous Chinese Lijiang breed and associated changes in phenotypes
R Yang, S Jin, S Fang, D Yan, H Zhang, J Nie… - Genetics Selection …, 2024 - Springer
Background Gene flow is crucial for enhancing economic traits of livestock. In China,
breeders have used hybridization strategies for decades to improve livestock performance …
breeders have used hybridization strategies for decades to improve livestock performance …
Constructing eRNA-mediated gene regulatory networks to explore the genetic basis of muscle and fat-relevant traits in pigs
C Wang, C Chen, B Lei, S Qin, Y Zhang, K Li… - Genetics Selection …, 2024 - Springer
Enhancer RNAs (eRNAs) play a crucial role in transcriptional regulation. While significant
progress has been made in understanding epigenetic regulation mediated by eRNAs …
progress has been made in understanding epigenetic regulation mediated by eRNAs …