The mitochondrial permeability transition (mPT) describes a Ca2+-dependent and
cyclophilin D (CypD)-facilitated increase of inner mitochondrial membrane permeability that …

Reactive oxidative species (ROS) toxicity remains an undisputed cause and link between
Alzheimer's disease (AD) and Type-2 Diabetes Mellitus (T2DM). Patients with both AD and …

Lipid peroxidation involves a cascade of reactions in which production of free radicals
occurs selectively in the lipid components of cellular membranes. Polyunsaturated fatty …

A great variety of compounds are formed during lipid peroxidation of polyunsaturated fatty
acids of membrane phospholipids. Among them, bioactive aldehydes, such as 4 …

Rapidly progressive Alzheimer's disease (rpAD) is a particularly aggressive form of
Alzheimer's disease, with a median survival time of 7–10 months after diagnosis. Why these …

Mitochondrial permeability transition pore (mPTP) plays a central role in alterations of
mitochondrial structure and function leading to neuronal injury relevant to aging and …

Oxidative stress has been proposed to be an important factor in the pathogenesis of
Alzheimer's disease (AD) and contributed to β-amyloid (A β) generation. Interaction between …

Transgenic mice overexpressing the P301L mutant human tau protein exhibit an
accumulation of hyperphosphorylated tau and develop neurofibrillary tangles. The …

SUMMARY ATP synthase, a double-motor enzyme, plays various roles in the cell,
participating not only in ATP synthesis but in ATP hydrolysis-dependent processes and in …

Alzheimer's disease, an age-related neurodegenerative disorder, is characterized clinically
by a progressive loss of memory and cognitive functions. Neuropathologically, Alzheimer's …