Type 1 diabetes mellitus is believed to result from destruction of the insulin-producing β-cells
in pancreatic islets that is mediated by autoimmune mechanisms. The classic view is that …

Fifty years since the first description of an association between HLA and human disease,
HLA molecules have proven to be central to physiology, protective immunity and …

The Major Histocompatibility Complex (MHC) locus encodes classical MHC class I and MHC
class II molecules and nonclassical MHC-I molecules. The architecture of these molecules is …

T cells are a critical part of the adaptive immune system that are able to distinguish between
healthy and unhealthy cells. Upon recognition of protein fragments (peptides), activated T …

T cell discrimination of self and non-self is predicated on αβ T cell receptor (TCR) co-
recognition of peptides presented by MHC molecules. Over the past 20 years, structurally …

The ability of mammals to mount adaptive immune responses culminating with the
establishment of immunological memory is predicated on the ability of the mature T cell …

Clonal selection theory proposed that individual T cells are specific for a single peptide–
MHC antigen. However, the repertoire of αβ T cell receptors (TCRs) is dwarfed by the vast …

T cell recognition of specific antigens mediates protection from pathogens and controls
neoplasias, but can also cause autoimmunity. Our knowledge of T cell antigens and their …

We studied the prevalent cytotoxic CD8 T cell response mounted against severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) Spike glycoprotein 269-277 epitope …

Type 1 diabetes (T1D) is a chronic autoimmune disease that causes severe loss of
pancreatic β cells. Autoreactive T cells are key mediators of β cell destruction. Studies of …