Osteopontin (OPN) is a bone sialoprotein involved in osteoclast attachment to mineralised
bone matrix, as well as being a bone matrix protein, OPN is also a versatile protein that acts …

Metastasis to bone frequently occurs in majority of patients with advanced breast cancer and
prostate cancer, leading to devastating skeletal-related events and substantially reducing …

Background & Aims Tumor-microenvironment factors and cancer stem cells (CSCs) play a
critical role in the aggressiveness of pancreatic cancer (PC). However, the degree to which …

Risk of cancer especially of colon, breast, and pancreas is high in diabetic and obese
patients, with potential involvement of augmented expression of RAGE (receptor for …

Complex interactions between tumor and host cells regulate systemic tumor dissemination,
a process that begins early at the primary tumor site and goes on until tumor cells detach …

Abstract Osteopontin (OPN), a chemokine-like protein, plays a crucial role in the proliferation
and metastasis of various cancers. However, how tumor stroma modulates the expression of …

Osteopontin (OPN), a multifunctional protein, has emerged as a potentially valuable
biomarker for diagnosing and treating cancers. Recent research focuses on its involvement …

Acidic pH is a crucial intrinsic property of the microenvironment of most solid tumors. Hence,
the use of pH sensitive tumor targeting nanoparticles is an attractive approach to enhance …

Acute myeloid leukemia (AML) is a highly heterogeneous malignancy of the blood and bone
marrow, characterized by clonal expansion of myeloid stem and progenitor cells and rapid …

Malignant tumor represents a major reason for death in the world and its incidence is
growing rapidly. Developing the tools for early diagnosis is possibly a promising way to offer …