Histone modifications and chromatin-associated protein complexes are crucially involved in
the control of gene expression, supervising cell fate decisions and differentiation. Many …

The Polycomb group (PcG) of proteins defines a subset of factors that physically associate
and function to maintain the positional identity of cells from the embryo to adult stages. PcG …

CpG islands (CGIs) are associated with most mammalian gene promoters. A subset of CGIs
act as polycomb response elements (PREs) and are recognized by the polycomb silencing …

Eukaryotic gene regulation involves a balance between packaging of the genome into
nucleosomes and enabling access to regulatory proteins and RNA polymerase …

Although important for gene regulation, most studies of genome organization use either
fluorescence in situ hybridization (FISH) or chromosome conformation capture (3C) …

Polycomb-repressive complex 1 (PRC1) and PRC2 maintain repression at many
developmental genes in mouse embryonic stem cells and are required for early …

Background The histone variant H2A. Z has been implicated in nucleosome exchange,
transcriptional activation and Polycomb repression. However, the relationships among these …

The DNA hypomethylation that occurs when embryonic stem cells (ESCs) are directed to the
ground state of naive pluripotency by culturing in two small molecule inhibitors (2i) results in …

Estrogen-related receptors (ERRα/β/γ) are orphan nuclear receptors that function in energy-
demanding physiological processes, as well as in development and stem cell maintenance …

Gene expression states influence the 3D conformation of the genome through poorly
understood mechanisms. Here, we investigate the conformation of the murine HoxB locus, a …