Cancer is increasingly becoming a serious threat to human life and health. Therefore, the
development of safe and effective therapeutic agents against the disease is of crucial …

Many active pharmaceutical ingredients show low oral bioavailability due to factors such as
poor solubility and physical and chemical instability. The formation of inclusion complexes …

Melanoma is a form of skin cancer that starts in melanocytes. Rampant chemo-resistance,
metastasis, and inability to cross the skin barriers and accumulate within the tumor …

The aim of this work is the development and production by Direct Powder Extrusion (DPE)
3D printing technique of novel oral mucoadhesive films delivering Clobetasol propionate …

The purpose of this study was to use hydroxypropyl-β-cyclodextrin (HP-β-CD) as a novel
carrier in solid SNEDDS and solid dispersions to enhance the solubility and oral …

Melanoma is the most malignant form of skin cancer across the globe. Conventional
therapies are currently ineffective which could be attributed to the rampant chemo …

Niclosamide (NCS) is a drug that has been used as an anthelmintic and anti-parasitic drug
for about 40 years. Recently, some studies have highlighted its potential in treating various …

Oral drug administration has become the most common and preferred mode of disease
treatment due to its good medication adherence and convenience. For orally administered …

Localized delivery of anticancer drugs is often the most useful therapeutic approach for the
treatment of solid tumors. The use of injectable polymeric systems that maximize drug …

We developed an amorphous solid dispersion (ASD) of the poorly water-soluble molecule
niclosamide that achieved a more than two-fold increase in bioavailability. Notably, this …