Acute Trypanosoma cruzi infections can be asymptomatic, but chronically infected
individuals can die of Chagas' disease. The transfer of the parasite mitochondrial kinetoplast …

As the science of immunology grows increasingly mechanistic, motivation for developing
quantitative, design-based engineering approaches has also evolved, both for therapeutic …

Antigens derived from apoptotic cell debris can drive clonal T-cell deletion or anergy, and
antigens chemically coupled ex vivo to apoptotic cell surfaces have been shown …

Up to 18 million of individuals are infected by the protozoan parasite Trypanosoma cruzi in
Latin America, one third of whom will develop chronic Chagas disease cardiomyopathy …

Chagas heart disease is caused by infection with the protozoan parasite Trypanosoma cruzi.
The apparent absence of parasites from the hearts of most individuals who succumb to this …

Captopril, an angiotensin-converting enzyme inhibitor, is widely used in the treatment of a
variety of cardiomyopathies, but its effect on autoimmune myocarditis has not been …

Background—Experimental autoimmune myocarditis (EAM) is a CD4+ T-cell–mediated
mouse model of postviral cardiomyopathy. Activation of interleukin-1 type 1 and Toll-like …

Infection with Trypanosoma cruzi, the agent of Chagas' disease, may induce antibodies and
T cells reactive with self antigens (autoimmunity). Because autoimmunity is generally …

The protozoan Trypanosoma cruzi causes chronic Chagas' disease myocarditis (CCDM) in
infected mammals. The pathogenesis of CCDM, however, is still unclear. Indirect evidence …

[Frontiers in Bioscience 8, e315-322, May 1,2003] 315 THE SIGNIFICANCE OF
AUTOIMMUNITY IN THE PATHOGENESIS OF CHAGAS HEART DISEA Page 1 [Frontiers in …