Critical reanalysis of the mechanisms underlying the cardiorenal benefits of SGLT2 inhibitors and reaffirmation of the nutrient deprivation signaling/autophagy …
M Packer - Circulation, 2022 - Am Heart Assoc
SGLT2 (sodium-glucose cotransporter 2) inhibitors produce a distinctive pattern of benefits
on the evolution and progression of cardiomyopathy and nephropathy, which is …
on the evolution and progression of cardiomyopathy and nephropathy, which is …
Prevention of cardiorenal damage: importance of albuminuria
LM Ruilope, A Ortiz, A Lucia, B Miranda… - European Heart …, 2023 - academic.oup.com
Chronic kidney disease (CKD) is projected to become a leading global cause of death by
2040, and its early detection is critical for effective and timely management. The current …
2040, and its early detection is critical for effective and timely management. The current …
Causal effects of specific gut microbiota on chronic kidney diseases and renal function—a two-sample Mendelian randomization study
Background: Targeting the gut microbiota may become a new therapeutic to prevent and
delay the progression of chronic kidney disease (CKD). Nonetheless, the causal relationship …
delay the progression of chronic kidney disease (CKD). Nonetheless, the causal relationship …
Molecular subtyping based on cuproptosis-related genes and characterization of tumor microenvironment infiltration in kidney renal clear cell carcinoma
ZH Ji, WZ Ren, HQ Wang, W Gao, B Yuan - Frontiers in Oncology, 2022 - frontiersin.org
The incidence of kidney renal clear cell carcinoma (KIRC) is rising worldwide, and the
prognosis is poor. Cuproptosis is a new form of cell death that is dependent on and …
prognosis is poor. Cuproptosis is a new form of cell death that is dependent on and …
The Rotterdam Study. Design update and major findings between 2020 and 2024
MA Ikram, BCT Kieboom, WP Brouwer… - European Journal of …, 2024 - Springer
Abstract The Rotterdam Study is a population-based cohort study, started in 1990 in the
district of Ommoord in the city of Rotterdam, the Netherlands, with the aim to describe the …
district of Ommoord in the city of Rotterdam, the Netherlands, with the aim to describe the …
The AMPK-Sirtuin 1-YAP axis is regulated by fluid flow intensity and controls autophagy flux in kidney epithelial cells
A Claude-Taupin, P Isnard, A Bagattin… - Nature …, 2023 - nature.com
Shear stress generated by urinary fluid flow is an important regulator of renal function. Its
dysregulation is observed in various chronic and acute kidney diseases. Previously, we …
dysregulation is observed in various chronic and acute kidney diseases. Previously, we …
Causal effects of systemic inflammatory regulators on chronic kidney diseases and renal function: a bidirectional Mendelian randomization study
H Li, M Li, C Liu, P He, A Dong, S Dong… - Frontiers in …, 2023 - frontiersin.org
Background While targeted systemic inflammatory modulators show promise in preventing
chronic kidney disease (CKD) progression, the causal link between specific inflammatory …
chronic kidney disease (CKD) progression, the causal link between specific inflammatory …
[HTML][HTML] A novel multi-ancestry proteome-wide Mendelian randomization study implicates extracellular proteins, tubular cells, and fibroblasts in estimated glomerular …
Estimated glomerular filtration rate (eGFR) impacts the concentration of plasma biomarkers
confounding biomarker association studies of eGFR with reverse causation. To identify …
confounding biomarker association studies of eGFR with reverse causation. To identify …
Genetic kidney diseases as an underrecognized cause of chronic kidney disease: the key role of international registry reports
Inherited kidney diseases (IKDs) are among the leading causes of early-onset chronic
kidney disease (CKD) and are responsible for at least 10–15% of cases of kidney …
kidney disease (CKD) and are responsible for at least 10–15% of cases of kidney …
[HTML][HTML] Genetic loci and prioritization of genes for kidney function decline derived from a meta-analysis of 62 longitudinal genome-wide association studies
Estimated glomerular filtration rate (eGFR) reflects kidney function. Progressive eGFR-
decline can lead to kidney failure, necessitating dialysis or transplantation. Hundreds of loci …
decline can lead to kidney failure, necessitating dialysis or transplantation. Hundreds of loci …