Branched-chain amino acid (BCAA) catabolism has been considered to have an emerging
role in the pathogenesis of metabolic disturbances in obesity and type 2 diabetes (T2D) …

The cause of insulin resistance in obesity and type 2 diabetes mellitus (T2DM) is not limited
to impaired insulin signalling but also involves the complex interplay of multiple metabolic …

Type 2 diabetes mellitus is the most prevalent metabolic disorder characterized by
hyperglycemia, hyperlipidemia as well as insulin resistance and is affecting the lives of a …

Excessive energy intake and reduced energy expenditure drive the development of insulin
resistance and metabolic diseases such as obesity and type 2 diabetes mellitus. Metabolic …

Background Epidemiological studies have shown that increased circulating branched-chain
amino acids (BCAAs) are associated with insulin resistance and type 2 diabetes (T2D). This …

Sensing and responding to changes in nutrient levels, including those of glucose, lipids, and
amino acids, by the body is necessary for survival. Accordingly, perturbations in nutrient …

Nonalcoholic fatty liver disease (NAFLD) is increasing in prevalence in concert with the
global epidemic of obesity and is being diagnosed at increasingly younger ages. The …

Metabolic syndrome (MetS) is a cluster of metabolic risk factors for diabetes, coronary heart
disease, non-alcoholic fatty liver disease, and some tumors. It includes insulin resistance …

The incidence of type 2 diabetes mellitus (T2DM) has increased dramatically at an alarming
level around the world. T2DM is associated with changeable risk factors in lifestyle as well …

Nonalcoholic fatty liver disease (NAFLD) is the liver manifestation of metabolic syndrome
and is the most common chronic liver disease in the world. The pathogenesis of NAFLD has …