Extending 2-D convolutional neural networks to 3-D for advancing deep learning cancer classification with application to MRI liver tumor differentiation

E Trivizakis, GC Manikis, K Nikiforaki… - IEEE journal of …, 2018 - ieeexplore.ieee.org
Deep learning (DL) architectures have opened new horizons in medical image analysis
attaining unprecedented performance in tasks such as tissue classification and …

Differentiating low from high-grade soft tissue sarcomas using post-processed imaging parameters derived from multiple DWI models

GC Manikis, K Nikiforaki, E Lagoudaki… - European Journal of …, 2021 - Elsevier
Purpose To investigate and histopathologically validate the role of model selection in the
design of novel parametric meta-maps towards the discrimination of low from high-grade soft …

T2, T2* and spin coupling ratio as biomarkers for the study of lipomatous tumors

K Nikiforaki, GC Manikis, E Kontopodis, E Lagoudaki… - Physica Medica, 2019 - Elsevier
Background Subcutaneous fat may have variable signal intensity on T2w images depending
on the choice of imaging parameters. However, fatty components within tumors have a …

Diffusion weighted imaging in patients with rectal cancer: Comparison between Gaussian and non-Gaussian models

GC Manikis, K Marias, DMJ Lambregts, K Nikiforaki… - PloS one, 2017 - journals.plos.org
Purpose The purpose of this study was to compare the performance of four diffusion models,
including mono and bi-exponential both Gaussian and non-Gaussian models, in diffusion …

T2-based MRI radiomic features for discriminating tumour grading in soft tissues sarcomas

GC Manikis, K Nikiforaki, E Lagoudaki… - Hellenic Journal οf …, 2019 - hjradiology.org
Purpose: The proposed study aims to develop an MRI-based radiomics analysis framework
and investigate the feasibility of the calculated quantitative imaging features for …

Validating the imaging biomarker: the proof of efficacy and effectiveness

GC Manikis, N Papanikolaou, C Matos - … Biomarkers: Development and …, 2017 - Springer
Medical imaging is an active and developing area, providing significant anatomical,
functional, and molecular information in a wide range of clinical and research studies …

The impact of spin coupling signal loss on fat content characterization in multi-echo acquisitions with different echo spacing

K Nikiforaki, GC Manikis, T Boursianis, K Marias… - Magnetic Resonance …, 2017 - Elsevier
Purpose This study aimed to assess the effect of echo spacing in transverse magnetization
(T2) signal decay of gel and fat (oil) samples. Additionally, we assess the feasibility of using …

Imaging Biomarker Model-Based Analysis

GC Manikis, E Kontopodis, K Nikiforaki… - … and Clinical Integration, 2017 - Springer
Magnetic resonance imaging (MRI) is an imaging technique that is based on the interactions
of water with external magnetic fields. Magnetic properties of water molecules are analyzed …

Addressing Intravoxel Incoherent Motion challenges through an optimized fitting framework for quantification of perfusion

GC Manikis, K Nikiforaki, G Ioannidis… - … on Imaging Systems …, 2016 - ieeexplore.ieee.org
Diffusion Weighted Imaging (DWI) is a noninvasive imaging technique in Magnetic
Resonance Imaging (MRI), providing significant anatomical and functional information in a …

Sparse Representations on DW-MRI: A study on pancreas

A Pentari, G Tsagkatakis, K Marias… - 2019 IEEE 19th …, 2019 - ieeexplore.ieee.org
This paper presents a method for reducing the Diffusion Weighted Magnetic Resonance
Imaging (DW-MRI) examination time based on the mathematical framework of sparse …