Malaria remains one of the biggest health problems in the world. While significant reductions
in malaria morbidity and mortality had been achieved from 2000 to 2015, the favorable trend …

Introduction Eradication of malaria remains one of the main aims of medicine. Despite
progress in malaria treatment, mortality rate remains high, especially in the poorest parts of …

The symptoms of malaria occur during the blood stage of infection, when parasites invade
and replicate within human erythrocytes. The PfPCRCR complex, containing PfRH5 (refs.,) …

Reticulocyte-binding protein homologue 5 (RH5), a leading blood-stage Plasmodium
falciparum malaria vaccine target, interacts with cysteine-rich protective antigen (CyRPA) …

Extensive control efforts have significantly reduced malaria cases and deaths over the past
two decades, but in recent years, coupled with the COVID-19 pandemic, success has …

Plasmodium falciparum is a human-adapted apicomplexan parasite that causes the most
dangerous form of malaria. P. falciparum cysteine-rich protective antigen (PfCyRPA) is an …

Vaccines against infectious diseases have had great successes in the history of public
health. Major breakthroughs have occurred in the development of vaccine-based …

PfRipr is a highly conserved asexual-blood stage malaria vaccine candidate against
Plasmodium falciparum. PfRipr5, a protein fragment of PfRipr inducing the most potent …

The malaria asexual blood-stage antigen PfRipr and its most immunogenic fragment PfRipr5
have recently risen as promising vaccine candidates against this infectious disease …

Plasmodium falciparum is the most lethal human malaria parasite, partly due to its genetic
variability and ability to use multiple invasion routes via its binding to host cell surface …