Chimeric antigen receptor (CAR) T cell therapy has garnered significant excitement due to
its success for hematological malignancies in clinical studies leading to the US Food and …

Glioblastoma multiforme (GBM) is the most common and aggressive malignant primary brain
tumor in adults. Current treatment options typically consist of surgery followed by …

Adaptive immunity, orchestrated by B-cells and T-cells, plays a crucial role in protecting the
body from pathogenic invaders and can be used as tools to enhance the body's defense …

Bispecific antibodies (bsAb) that target two independent epitopes or antigens have been
extensively explored in translational and clinical studies since they were first developed in …

Breast cancer rises as the most commonly diagnosed cancer in 2020. Among women,
breast cancer ranks first in both cancer incidence rate and mortality. Treatment resistance …

Triple-negative breast cancer (TNBC), a highly aggressive breast cancer subtype that lacks
estrogen receptor, progesterone receptor, and HER2 expression, does not respond to …

Introduction Most breast cancer-related deaths arise from triple-negative breast cancer
(TNBC). Molecular heterogeneity, aggressiveness and the lack of effective therapies are …

New approaches to cancer immunotherapy have been developed, showing the ability to
harness the immune system to treat and eliminate cancer. For many solid tumors, therapy …

Genetically engineered T cells have been successfully used in the treatment of
hematological malignancies, greatly increasing both progression-free and overall survival in …

Vitiligo is an autoimmune skin disease characterized by melanocyte destruction. Regulatory
T cells (Tregs) are greatly reduced in vitiligo skin, and replenishing peripheral skin Tregs …