In response to a wide range of stimulations, host cells activate pyroptosis, a kind of
inflammatory cell death which is provoked by the cytosolic sensing of danger signals and …

Cochlear implantation has become the standard‐of‐care for adults and children with severe
to profound hearing loss. There is growing evidence that qualitative as well as quantitative …

Usher syndrome (USH) is the most common genetic condition responsible for combined loss
of hearing and vision. Balance disorders and bilateral vestibular areflexia are also observed …

Background Cochlear implantation is an effective habilitation modality for adults with
significant hearing loss. However, post-implant performance is variable. A portion of this …

With diverse etiologies and clinical features, the management of pediatric auditory
neuropathy spectrum disorder (ANSD) is often challenging, and the outcomes of cochlear …

Recessive PJVK mutations that cause a deficiency of pejvakin, a protein expressed in both
sensory hair cells and first-order neurons of the inner ear, are an important cause of …

Objectives To investigate speech and language outcomes in children with cochlear implants
(CIs) who had mutations in common deafness genes and to compare their performances …

Advances in next-generation sequencing technologies have led to elucidation of
sensorineural hearing loss genetics and associated clinical impacts. However, studies on …

Autosomal dominant non-syndromic hearing loss (ADNSHL) displays gene-specific
progression of hearing loss, which is amenable to sequential audioprofiling. We sought to …

Many genetic forms of congenital deafness affect the sound reception antenna of cochlear
sensory cells, the hair bundle. The resulting sensory deprivation jeopardizes auditory cortex …