[HTML][HTML] One-carbon metabolism and nucleotide biosynthesis as attractive targets for anticancer therapy

O Shuvalov, A Petukhov, A Daks, O Fedorova… - Oncotarget, 2017 - ncbi.nlm.nih.gov
Cancer-related metabolism has recently emerged as one of the “hallmarks of cancer”. It has
several important features, including altered metabolism of glucose and glutamine …

Interplay between p53 and non-coding RNAs in the regulation of EMT in breast cancer

S Parfenyev, A Singh, O Fedorova, A Daks… - Cell death & …, 2021 - nature.com
The epithelial–mesenchymal transition (EMT) plays a pivotal role in the differentiation of
vertebrates and is critically important in tumorigenesis. Using this evolutionarily conserved …

Baicalin, the major component of traditional Chinese medicine Scutellaria baicalensis induces colon cancer cell apoptosis through inhibition of oncomiRNAs

Y Tao, S Zhan, Y Wang, G Zhou, H Liang, X Chen… - Scientific reports, 2018 - nature.com
Colorectal cancer (CRC) is among the most frequently occurring cancers worldwide.
Baicalin is isolated from the roots of Scutellaria baicalensis and is its dominant flavonoid …

[HTML][HTML] Transcriptional profiling identifies the long noncoding RNA plasmacytoma variant translocation (PVT1) as a novel regulator of the asthmatic phenotype in …

PJ Austin, E Tsitsiou, C Boardman, SW Jones… - Journal of Allergy and …, 2017 - Elsevier
Background The mechanism underlying nonsevere and severe asthma remains unclear,
although it is commonly associated with increased airway smooth muscle (ASM) mass. Long …

Expression and clinical significance of the long non-coding RNA PVT1 in human gastric cancer

J Ding, D Li, M Gong, J Wang, X Huang… - OncoTargets and …, 2014 - Taylor & Francis
Background Highly sensitive markers are urgently needed for the diagnosis and grading of
gastric cancer and for managing drug resistance. The recent identification of long-non …

MicroRNA-202 maintains spermatogonial stem cells by inhibiting cell cycle regulators and RNA binding proteins

J Chen, T Cai, C Zheng, X Lin, G Wang… - Nucleic acids …, 2017 - academic.oup.com
Abstract miRNAs play important roles during mammalian spermatogenesis. However, the
function of most miRNAs in spermatogenesis and the underlying mechanisms remain …

PVT1 signaling is a mediator of cancer progression

C Derderian, AT Orunmuyi, EO Olapade-Olaopa… - Frontiers in …, 2019 - frontiersin.org
There is increasing evidence that PVT1 has oncogenic properties and regulates proliferation
and growth of many cancers. Themolecular mechanisms of action of PVT1 are mediated, in …

MicroRNA-23b targets Ras GTPase-activating protein SH3 domain-binding protein 2 to alleviate fibrosis and albuminuria in diabetic nephropathy

B Zhao, H Li, J Liu, P Han, C Zhang, H Bai… - Journal of The …, 2016 - journals.lww.com
Diabetic nephropathy (DN) is a frequent and severe complication of diabetes that is
structurally characterized by glomerular basement membrane thickening, extracellular …

microRNA and lung cancer

VD Vescovo, MA Denti - microRNA: Cancer: From Molecular Biology to …, 2015 - Springer
Lung cancer is the leading cause of cancer mortality worldwide. microRNAs (miRNAs) have
been established as players with a relevant role in lung cancer development, epithelial …

[HTML][HTML] MicroRNAs as lung cancer biomarkers

V Del Vescovo, M Grasso, M Barbareschi… - World journal of …, 2014 - ncbi.nlm.nih.gov
Lung cancer is the leading cause of cancer mortality worldwide. Its high mortality is due to
the poor prognosis of the disease caused by a late disease presentation, tumor …