Prokaryotic heme biosynthesis: multiple pathways to a common essential product

HA Dailey, TA Dailey, S Gerdes, D Jahn… - Microbiology and …, 2017 - Am Soc Microbiol
The advent of heme during evolution allowed organisms possessing this compound to
safely and efficiently carry out a variety of chemical reactions that otherwise were difficult or …

5‐Aminolevulinic acid‐based photodynamic therapy: clinical research and future challenges

Q Peng, T Warloe, K Berg, J Moan… - … Journal of the …, 1997 - Wiley Online Library
BACKGROUND Photodynamic therapy (PDT) for cancer patients has developed into an
important new clinical treatment modality in the past 25 years. PDT involves administration …

Proteomic mapping of mitochondria in living cells via spatially restricted enzymatic tagging

HW Rhee, P Zou, ND Udeshi, JD Martell, VK Mootha… - Science, 2013 - science.org
Microscopy and mass spectrometry (MS) are complementary techniques: The former
provides spatiotemporal information in living cells, but only for a handful of recombinant …

Structure and function of enzymes in heme biosynthesis

G Layer, J Reichelt, D Jahn, DW Heinz - Protein Science, 2010 - Wiley Online Library
Tetrapyrroles like hemes, chlorophylls, and cobalamin are complex macrocycles which play
essential roles in almost all living organisms. Heme serves as prosthetic group of many …

Tissue-specific regulation of iron metabolism and heme synthesis: distinct control mechanisms in erythroid cells

P Ponka - Blood, The Journal of the American Society of …, 1997 - ashpublications.org
Thrombopoietin (TPO) is the primary hematopoietic growth let counts, the cells of the
proximal convoluted tubules of factor involved in the regulation of platelet production. Al- the …

[图书][B] Amino acid metabolism

DA Bender - 2012 - books.google.com
Amino Acid Metabolism, 3rd Edition covers all aspects of the biochemistry and nutritional
biochemistry of the amino acids. Starting with an overview of nitrogen fixation and the …

[HTML][HTML] One ring to rule them all: trafficking of heme and heme synthesis intermediates in the metazoans

I Hamza, HA Dailey - Biochimica et Biophysica Acta (BBA)-Molecular Cell …, 2012 - Elsevier
The appearance of heme, an organic ring surrounding an iron atom, in evolution forever
changed the efficiency with which organisms were able to generate energy, utilize gasses …

Identification of a mammalian mitochondrial porphyrin transporter

PC Krishnamurthy, G Du, Y Fukuda, D Sun, J Sampath… - Nature, 2006 - nature.com
The movement of anionic porphyrins (for example, haem) across intracellular membranes is
crucial to many biological processes, but their mitochondrial translocation and coordination …

The biochemistry of heme biosynthesis

IU Heinemann, M Jahn, D Jahn - Archives of biochemistry and biophysics, 2008 - Elsevier
Heme is an integral part of proteins involved in multiple electron transport chains for energy
recovery found in almost all forms of life. Moreover, heme is a cofactor of enzymes including …

Protoporphyrinogen oxidase-inhibiting herbicides

SO Duke, J Lydon, JM Becerril, TD Sherman… - Weed Science, 1991 - cambridge.org
Several commercial and experimental herbicides such as p-nitrodiphenyl ethers,
oxadiazoles, and cyclic imides inhibit protoporphyrinogen IX oxidase (Protox), the enzyme …