Cellular senescence is a stable cell cycle arrest that can be triggered in normal cells in
response to various intrinsic and extrinsic stimuli, as well as developmental signals …

The skin is the largest organ and has a key protective role. Similar to any other tissue, the
skin is influenced not only by intrinsic/chronological aging, but also by extrinsic aging …

Low back pain (LBP) is a leading cause of labour loss and disability worldwide, and it also
imposes a severe economic burden on patients and society. Among symptomatic LBP …

The human skin is exposed daily to different environmental factors such as air pollutants and
ultraviolet (UV) light. Air pollution is considered a harmful environmental risk to human skin …

Intervertebral disc degeneration (IVDD) is a frequent and intractable chronic condition in
orthopedics that causes enormous discomfort in patients' lives and thoughts, as well as a …

Recent investigations into heterochronic parabiosis have unveiled robust rejuvenating
effects of young blood on aged tissues. However, the specific rejuvenating mechanisms …

Aging is a complex process characterized by an ongoing decline in physiological functions,
leading to degenerative diseases and an increased probability of death. Cellular …

Taurine, a naturally occurring sulfur-containing amino acid, has attracted significant attention
in recent years due to its potential health benefits. Found in various foods and often used in …

Abstract Therapy-Induced Senescence (TIS) is an established response to anticancer
therapy in a variety of cancer models. Ample evidence has characterized the triggers …

The key issue in the treatment of solid tumors is the lack of efficient strategies for the targeted
delivery and accumulation of therapeutic cargoes in the tumor microenvironment (TME) …