Over the last three decades acute liver failure (ALF) has been transformed from a rare and
poorly understood condition with a near universally fatal outcome, to one with a well …

Mechanisms of Disease: The Blood-Brain Barrier : Neurosurgery Mechanisms of Disease: The
Blood-Brain Barrier : Neurosurgery NEUROSURGERY PUBLICATIONS NEUROSURGERY …

Cerebral oedema is a devastating consequence of acute liver failure (ALF) and may be
associated with the development of intracranial hypertension and death. In ALF, some …

Acute liver failure (ALF) results in alterations of energy metabolites and of glucose‐derived
amino acid neurotransmitters in brain. However, the dynamics of changes in glucose …

One proposed mechanism for acute and chronic hepatic encephalopathy (HE) is a
disturbance in cerebral energy metabolism. It also reviews the current status of this …

Negative blood oxygenation–level dependent (BOLD) signal observed during task
execution in functional magnetic resonance imaging (fMRI) can be caused by different …

Hepatic encephalopathy and brain edema are important complications in the course of a
patient with acute liver failure. Presumed unrelated for many years, increasing evidence …

Hepatic encephalopathy can be a serious complication of acute liver failure and chronic liver
diseases, predominantly liver cirrhosis. Hyperammonemia plays the most important role in …

Fulminant hepatic failure (FHF) is often complicated by high intracranial pressure (ICP) and
fatal brain damage. In this study, we determined if a rise in [glutamate] ec and [lactate] ec …

The dynamics of l-lactate transport across the blood–brain barrier (BBB) and its cerebral
metabolism are still subject to debate. We studied lactate uptake and intracellular …