Histone deacetylase (HDAC) inhibitors are powerful epigenetic regulators that have
enormous therapeutic potential and have pleiotropic effects at the cellular and systemic …

Transcriptional regulation in eukaryotes occurs within a chromatin setting, and is strongly
influenced by the post-translational modification of histones, the building blocks of …

Acute myeloid leukemia (AML) is a hematological malignancy characterized by uncontrolled
proliferation, differentiation arrest, and accumulation of immature myeloid progenitors …

The opposing actions of histone acetyltransferases (HATs) and histone deacetylases
(HDACs) allow gene expression to be exquisitely regulated through chromatin remodelling …

Abstract Development can be altered to match phenotypes with the environment, and the
genetic mechanisms that direct such alternative phenotypes are beginning to be elucidated …

Cyclin D1 is an important regulator of cell cycle progression and can function as a
transcriptionl co-regulator. The overexpression of cyclin D1 has been linked to the …

Epigenetics has long been recognized as a significant field in biology and is defined as the
investigation of any alteration in gene expression patterns that is not attributed to changes in …

Deaths from breast cancer have fallen markedly over the past decade due, in part, to the use
of endocrine agents that reduce the levels of circulating oestrogens or compete with …

Histone deacetylases (HDACs)—enzymes that affect the acetylation status of histones and
other important cellular proteins—have been recognized as potentially useful therapeutic …

With a lifetime risk estimated to be one in eight in industrialized countries, breast cancer is
the most frequent type of cancer among women worldwide. Patients are often treated with …