Abstract Sphingosine-1-phosphate (S1P) is a signaling lipid, synthetized by sphingosine
kinases (SPHK1 and SPHK2), that affects cardiovascular function in various ways. S1P …

Histones control gene expression by modulating the structure of chromatin and the
accessibility of regulatory DNA sequences to transcriptional activators and repressors …

Sphingosine 1-phosphate (S1P) is a bioactive lysolipid with pleiotropic functions mediated
through a family of G proteincoupled receptors, S1P1, 2, 3, 4, 5. Physiological effects of S1P …

Human umbilical vein endothelial cells (HUVECs) have played a major role as a model
system for the study of the regulation of endothelial cell function and the role of the …

The five known members of the sphingosine-1-phosphate (S1P) receptor family exhibit
diverse tissue expression profiles and couple to distinct G-protein-mediated signalling …

Sphingosine 1-phosphate (S1P), an evolutionarily conserved bioactive lipid mediator, is
now recognized as a potent modulator of cell regulation. In vertebrates, S1P interacts with …

Angiogenesis is implicated in the pathogenesis of cancer, rheumatoid arthritis, and
atherosclerosis and in the treatment of coronary artery and peripheral vascular disease …

Sphingolipids are a structural component of the cell membrane, derived from sphingosine,
an amino alcohol. Its sphingoid base undergoes various types of enzymatic transformations …

Epoxyeicosatrienoic acids (EETs) reduce infarction of the myocardium after ischemia-
reperfusion injury to rodent and dog hearts mainly by opening sarcolemmal and …

Agonist activation of a subset of G protein coupled receptors (GPCRs) stimulates cell
proliferation, mimicking the better known effects of tyrosine kinase growth factors. Cell …