The development of biotechnological protocols based on cationic surfactants is a modern
trend focusing on the fabrication of antimicrobial and bioimaging agents, supramolecular …

Self-assembled synthetic gene delivery systems represent the bottom-up approach to gene
delivery and gene silencing, in which scientists are designing novel cationic and procationic …

Nonviral gene therapy using gemini surfactants is a unique approach to medicine that can
be adapted toward the treatment of various diseases. Recently, gemini surfactants have …

Hypoxia is a common feature of solid tumors contributing to resistance to chemotherapy.
Selective delivery of chemotherapeutic drugs to hypoxic tumor niche remains an unsolved …

Herein, for the first time the complexation ability of a homological series of
triphenylphosphonium surfactants (TPPB-n) toward DNA decamers has been explored …

A series of aromatic/heterocyclic bis-sulfonamides were synthesized from three established
aminosulfonamide carbonic anhydrase (CA, EC 4.2. 1.1) inhibitor pharmacophores, coupled …

Synthetic vectors for therapeutic nucleic acid delivery are currently competing significantly
with their viral counter parts due to their reduced immunogenicity, large payload capacity …

Diseases that are linked to defective genes or mutations can in principle be cured by gene
therapy, in which damaged or absent genes are either repaired or replaced by new DNA in …

The scope of RNAi based therapeutics is unquestionable. However, if we dissect the current
trend of clinical trials for afore mentioned drug class, some stark trends appear: 1) naked …

The use of cell-penetrating peptides (CPPs), typically HIV-Tat, to deliver therapeutic genes
for cancer treatment is hampered by the inefficient delivery and complicated uptake route of …