The intercalated disc (ID) is a highly specialized structure that connects cardiomyocytes via
mechanical and electrical junctions. Although described in some detail by light microscopy …

The heart works as a functional syncytium, which is realized via cell-cell coupling
maintained by gap junction channels. These channels connect two adjacent cells, so that …

In cardiomyocytes, the rapid depolarisation of the membrane potential is mediated by the α‐
subunit of the cardiac voltage‐gated Na+ channel (NaV1. 5), encoded by the gene SCN5A …

It has been proposed that when gap junctional coupling is reduced in cardiac tissue, action
potential propagation can be supported via ephaptic coupling, a mechanism mediated by …

Electrical conduction in cardiac ventricular tissue is regulated via sodium (Na+) channels
and gap junctions (GJs). We and others have recently shown that Na+ channels …

This white paper is the outcome of the seventh UC Davis Cardiovascular Research
Symposium on Systems Approach to Understanding Cardiovascular Disease and …

Introduction: In addition to gap junction conduction, recent reports implicate possible
ephaptic coupling contributions to action potential (AP) propagation between successive …

Within this work, we investigate how physiologically observed microstructural changes
induced by myocardial infarction impact the elastic parameters of the heart. We use the …

The term “excitation–contraction (EC) coupling” was introduced by Alexander Sandow
(Sandow, 1952) as “the entire sequence of reactions—excitation, inward acting link, and …

Cardiac voltage-gated sodium channel gain-of-function prolongs repolarization in the long-
QT syndrome type 3 (LQT3). Previous studies suggest that narrowing the perinexus within …