Bassoon and Piccolo are two very large scaffolding proteins of the cytomatrix assembled at
the active zone (CAZ) where neurotransmitter is released. They share regions of high …

Age-related skeletal muscle degradation known as “sarcopenia” exerts considerable strain
on public health systems globally. While the pathogenesis of such atrophy is undoubtedly …

Neuromuscular junction assembly and plasticity during embryonic, postnatal, and adult life
are tightly regulated by the continuous cross-talk among motor nerve endings, muscle fibers …

The synapse between motor neurons and skeletal muscle is known as the neuromuscular
junction (NMJ). Proper alignment of presynaptic and post-synaptic structures of motor …

Neuromuscular junctions (NMJs) are excitatory chemical synapses formed between nerve
terminals of spinal cord motor neurons and skeletal muscle fibers that use acetylcholine as …

Patients with Charcot–Marie–Tooth Type 2D (CMT2D), caused by dominant mutations in
Glycl tRNA synthetase (GARS), present with progressive weakness, consistently in the …

Study of the electrophysiological function of the neuromuscular junction (NMJ) is
instrumental in the understanding of the symptoms and pathophysiology of myasthenia …

Aging is known as a major risk factor for the structure and function of the nervous system.
There is urgent need to overcome such deleterious effects of age-related …

The neuromuscular junction (NMJ), a cellular synapse between a motor neuron and a
skeletal muscle fiber, enables the translation of chemical cues into physical activity. The …

Highlights•The neuromuscular junction is highly adaptable to exercise training both
physiologically and morphologically.•Training-induced adaptations occur at both the …