[HTML][HTML] Outcomes are similar after allogeneic hematopoietic stem cell transplant for newly diagnosed acute myeloid leukemia patients who received venetoclax+ …

AC Winters, G Bosma, D Abbott, M Minhajuddin… - … and Cellular Therapy, 2022 - Elsevier
Allogeneic hematopoietic stem cell transplantation (SCT) after a patient with acute myeloid
leukemia (AML) achieves a remission from intensive chemotherapy (IC) is given with …

Venetoclax with decitabine versus decitabine monotherapy in elderly acute myeloid leukemia: a propensity score-matched analysis

D Kwag, BS Cho, SY Bang, JH Lee, GJ Min… - Blood Cancer …, 2022 - nature.com
Venetoclax (VEN) combined with azacitidine (AZA) or decitabine (DEC) has been approved
for older adults with acute myeloid leukemia (AML) unfit for intensive chemotherapy based …

Comparative analysis of Bcl-2 family protein overexpression in CAR T cells alone and in combination with BH3 mimetics

F Korell, ML Olson, D Salas-Benito, MB Leick… - Science Translational …, 2024 - science.org
Approximately 50% of patients with hematologic malignancies relapse after chimeric antigen
receptor (CAR) T cell treatment; mechanisms of failure include loss of CAR T persistence …

Venetoclax-based treatment in acute myeloid leukemia: an unexpected bonus on the path to allogeneic hematopoietic stem cell transplant?

F Tarantini, C Cumbo, L Anelli, A Zagaria… - Leukemia & …, 2024 - Taylor & Francis
Despite the approval of new drugs, the inclusion of-omics-derived data and the integration of
machine learning in both the diagnostic and therapeutic process, the prognosis of acute …

Selinexor Synergistically Promotes the Antileukemia Activity of Venetoclax in Acute Myeloid Leukemia by Inhibiting Glycolytic Function and Downregulating the …

J Jiang, Y Wang, D Liu, X Wang, Y Zhu… - ImmunoTargets and …, 2023 - Taylor & Francis
Introduction The BCL-2 inhibitor venetoclax has been widely used in the treatment of acute
myeloid leukemia (AML); however, AML patients treated with venetoclax gradually develop …

A successful bridge therapy combining hypomethylating agents with venetoclax for adult patients with newly diagnosed or relapsed/refractory acute myeloid leukemia

SY Bang, S Park, D Kwag, JH Lee, GJ Min, SS Park… - Cancers, 2023 - mdpi.com
Simple Summary The introduction of venetoclax (VEN) to combination regimens has
dramatically changed the paradigm of treatment for acute myeloid leukemia (AML) patients …

The approach of HMA plus VEN with or without BMT for all patients with AML

HJ Male, TL Lin - Hematology, 2023 - ashpublications.org
Abstract Treatment options for acute myeloid leukemia (AML) have expanded over the last 5
years. New regimens are increasing the options for patients who previously may not have …

[PDF][PDF] 维奈克拉联合方案一线治疗新诊断急性髓系白血病的单中心真实世界研究

吴迪, 陈智超, 黎纬明 - 临床血液学杂志, 2024 - lcxy.whuhzzs.com
目的: 靶向药物BCL-2 抑制剂维奈克拉(venetoclax, VEN) 的出现革新了急性髓系白血病(acute
myeloidleukemia, AML) 的治疗格局, 尤其是对于老年或不适合强化疗的患者 …

The Goldilocks dilemma in AML: Too young and fit, but not young and fit enough

ECS Martin, TY Zhang, GN Mannis - Clinical Lymphoma Myeloma and …, 2023 - Elsevier
Discussion It is well-described that increasing age—and in particular age greater than 60
years old—is a risk factor for poorer response to traditional intensive induction …

A Remission by Any Other Means May Smell as Sweet

GN Mannis, LS Muffly - The Hematologist, 2024 - ashpublications.org
In the second act of Shakespeare's Romeo and Juliet, Juliet argues that despite Romeo
being of Montague—and not Capulet—lineage, their burgeoning love affair should be …