5-HT receptors expressed throughout the human body are targets for established
therapeutics and various drugs in development. Their diversity of structure and function …

Major depressive disorder is a serious mental disorder that profoundly affects an individual's
quality of life. Although the aetiologies underlying this disorder remain unclear, an …

Here we conducted a large-scale genetic association analysis of educational attainment in a
sample of approximately 1.1 million individuals and identify 1,271 independent genome …

The α7 nicotinic acetylcholine receptor plays critical roles in the central nervous system and
in the cholinergic inflammatory pathway. This ligand-gated ion channel assembles as a …

Accumulation of lactate in the tissue microenvironment is a feature of both inflammatory
disease and cancer. Here, we assess the response of immune cells to lactate in the context …

Nicotinic acetylcholine receptors are ligand-gated ion channels that mediate fast chemical
neurotransmission at the neuromuscular junction and have diverse signalling roles in the …

The neurotransmitter acetylcholine (ACh) can regulate neuronal excitability by acting on the
cys-loop cation-conducting ligand-gated nicotinic ACh receptor (nAChR) channels. These …

There is a continued desire in biomedical research to reduce the number and duration of
design cycles required to optimize lead compounds into high-quality chemical probes or …

Mitochondria from many eukaryotic clades take up large amounts of calcium (Ca2+) via an
inner membrane transporter called the uniporter. Transport by the uniporter is membrane …

Four major receptor families enable cells to respond to chemical and physical signals from
their proximal environment. The ligand-and voltage-gated ion channels, G-protein-coupled …