Designing cell function: assembly of synthetic gene circuits for cell biology applications
M Xie, M Fussenegger - Nature Reviews Molecular Cell Biology, 2018 - nature.com
Synthetic biology is the discipline of engineering application-driven biological functionalities
that were not evolved by nature. Early breakthroughs of cell engineering, which were based …
that were not evolved by nature. Early breakthroughs of cell engineering, which were based …
Tailoring biomaterials for cancer immunotherapy: emerging trends and future outlook
Cancer immunotherapy, as a paradigm shift in cancer treatment, has recently received
tremendous attention. The active cancer vaccination, immune checkpoint blockage (ICB) …
tremendous attention. The active cancer vaccination, immune checkpoint blockage (ICB) …
Control of the activity of CAR-T cells within tumours via focused ultrasound
Focused ultrasound can deliver energy safely and non-invasively into tissues at depths of
centimetres. Here we show that the genetics and cellular functions of chimeric antigen …
centimetres. Here we show that the genetics and cellular functions of chimeric antigen …
Large-scale design of robust genetic circuits with multiple inputs and outputs for mammalian cells
BH Weinberg, NTH Pham, LD Caraballo… - Nature …, 2017 - nature.com
Engineered genetic circuits for mammalian cells often require extensive fine-tuning to
perform as intended. We present a robust, general, scalable system, called'Boolean logic …
perform as intended. We present a robust, general, scalable system, called'Boolean logic …
Control theory meets synthetic biology
The past several years have witnessed an increased presence of control theoretic concepts
in synthetic biology. This review presents an organized summary of how these control …
in synthetic biology. This review presents an organized summary of how these control …
An oxygen sensitive self-decision making engineered CAR T-cell
A Juillerat, A Marechal, JM Filhol, Y Valogne, J Valton… - Scientific reports, 2017 - nature.com
A key to the success of chimeric antigen receptor (CAR) T-cell based therapies greatly rely
on the capacity to identify and target antigens with expression restrained to tumor cells. Here …
on the capacity to identify and target antigens with expression restrained to tumor cells. Here …
Stimuli-responsive engineered living materials
Stimuli-responsive materials are able to undergo controllable changes in materials
properties in response to external cues. Increasing efforts have been directed towards …
properties in response to external cues. Increasing efforts have been directed towards …
Synthetic biology—the synthesis of biology
S Ausländer, D Ausländer… - Angewandte Chemie …, 2017 - Wiley Online Library
Synthetic biology concerns the engineering of man‐made living biomachines from
standardized components that can perform predefined functions in a (self‐) controlled …
standardized components that can perform predefined functions in a (self‐) controlled …
Synthetic biology-inspired cell engineering in diagnosis, treatment, and drug development
N Zhao, Y Song, X Xie, Z Zhu, C Duan… - … and Targeted Therapy, 2023 - nature.com
The fast-developing synthetic biology (SB) has provided many genetic tools to reprogram
and engineer cells for improved performance, novel functions, and diverse applications …
and engineer cells for improved performance, novel functions, and diverse applications …
Engineering versatile nanomedicines for ultrasonic tumor immunotherapy
J Liang, X Qiao, L Qiu, H Xu, H Xiang, H Ding… - Advanced …, 2024 - Wiley Online Library
Due to the specific advantages of ultrasound (US) in therapeutic disease treatments, the
unique therapeutic US technology has emerged. In addition to featuring a low‐invasive …
unique therapeutic US technology has emerged. In addition to featuring a low‐invasive …