Designing cell function: assembly of synthetic gene circuits for cell biology applications

M Xie, M Fussenegger - Nature Reviews Molecular Cell Biology, 2018 - nature.com
Synthetic biology is the discipline of engineering application-driven biological functionalities
that were not evolved by nature. Early breakthroughs of cell engineering, which were based …

Tailoring biomaterials for cancer immunotherapy: emerging trends and future outlook

C Wang, Y Ye, Q Hu, A Bellotti, Z Gu - Advanced materials, 2017 - Wiley Online Library
Cancer immunotherapy, as a paradigm shift in cancer treatment, has recently received
tremendous attention. The active cancer vaccination, immune checkpoint blockage (ICB) …

Control of the activity of CAR-T cells within tumours via focused ultrasound

Y Wu, Y Liu, Z Huang, X Wang, Z Jin, J Li… - Nature biomedical …, 2021 - nature.com
Focused ultrasound can deliver energy safely and non-invasively into tissues at depths of
centimetres. Here we show that the genetics and cellular functions of chimeric antigen …

Large-scale design of robust genetic circuits with multiple inputs and outputs for mammalian cells

BH Weinberg, NTH Pham, LD Caraballo… - Nature …, 2017 - nature.com
Engineered genetic circuits for mammalian cells often require extensive fine-tuning to
perform as intended. We present a robust, general, scalable system, called'Boolean logic …

Control theory meets synthetic biology

D Del Vecchio, AJ Dy, Y Qian - Journal of The Royal …, 2016 - royalsocietypublishing.org
The past several years have witnessed an increased presence of control theoretic concepts
in synthetic biology. This review presents an organized summary of how these control …

An oxygen sensitive self-decision making engineered CAR T-cell

A Juillerat, A Marechal, JM Filhol, Y Valogne, J Valton… - Scientific reports, 2017 - nature.com
A key to the success of chimeric antigen receptor (CAR) T-cell based therapies greatly rely
on the capacity to identify and target antigens with expression restrained to tumor cells. Here …

Stimuli-responsive engineered living materials

LK Rivera-Tarazona, ZT Campbell, TH Ware - Soft Matter, 2021 - pubs.rsc.org
Stimuli-responsive materials are able to undergo controllable changes in materials
properties in response to external cues. Increasing efforts have been directed towards …

Synthetic biology—the synthesis of biology

S Ausländer, D Ausländer… - Angewandte Chemie …, 2017 - Wiley Online Library
Synthetic biology concerns the engineering of man‐made living biomachines from
standardized components that can perform predefined functions in a (self‐) controlled …

Synthetic biology-inspired cell engineering in diagnosis, treatment, and drug development

N Zhao, Y Song, X Xie, Z Zhu, C Duan… - … and Targeted Therapy, 2023 - nature.com
The fast-developing synthetic biology (SB) has provided many genetic tools to reprogram
and engineer cells for improved performance, novel functions, and diverse applications …

Engineering versatile nanomedicines for ultrasonic tumor immunotherapy

J Liang, X Qiao, L Qiu, H Xu, H Xiang, H Ding… - Advanced …, 2024 - Wiley Online Library
Due to the specific advantages of ultrasound (US) in therapeutic disease treatments, the
unique therapeutic US technology has emerged. In addition to featuring a low‐invasive …