Stem cells and their local microenvironment, or niche, communicate through mechanical
cues to regulate cell fate and cell behaviour and to guide developmental processes. During …

Heterotrimeric guanine-nucleotide-binding regulatory proteins (G-proteins) mainly relay the
information from G-protein-coupled receptors (GPCRs) on the plasma membrane to the …

The cells and tissues of the human body are constantly exposed to exogenous and
endogenous forces that are referred to as biomechanical cues. They guide and impact …

Many genes and molecules that drive tissue patterning during organogenesis and tissue
regeneration have been discovered. Yet, we still lack a full understanding of how these …

The ability of cells to divide asymmetrically is essential for generating diverse cell types
during development. The past 10 years have seen tremendous progress in our …

The orientation of the mitotic spindle has been proposed to control cell fate choices, tissue
architecture, and tissue morphogenesis. Here, we review the mechanisms regulating the …

The par genes were discovered in genetic screens for regulators of cytoplasmic partitioning
in the early embryo of C. elegans, and encode six different proteins required for asymmetric …

Cell division is commonly thought to involve the equal distribution of cellular components
into the two daughter cells. During many cell divisions, however, proteins, membrane …

Heterotrimeric G-proteins are intracellular partners of G-protein-coupled receptors (GPCRs).
GPCRs act on inactive Gα· GDP/Gβγ heterotrimers to promote GDP release and GTP …

Intracellular and extracellular mechanical forces affect the structure and dynamics of the
actin cytoskeleton. However, the underlying molecular and biophysical mechanisms …